node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
hisA | hisA2 | plu1566 | plu0797 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Unnamed protein product; Similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.921 |
hisA | hisB | plu1566 | plu1568 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-phosphatase/imisazoleglycerol- phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.997 |
hisA | hisD | plu1566 | plu1569 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.998 |
hisA | hisF | plu1566 | plu1565 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit HisF (IGP synthase cyclase subunit); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.997 |
hisA | hisG | plu1566 | plu1570 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.987 |
hisA | hisH | plu1566 | plu1567 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.998 |
hisA | hisI | plu1566 | plu1564 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase (PRA-CH) / phosphoribosyl-ATP pyrophosphatase (PRA-PH); In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisA | metL | plu1566 | plu4755 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; homoserine dehydrogenase II]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.553 |
hisA | thrA | plu1566 | plu0563 | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Aspartokinase I-homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.553 |
hisA2 | hisA | plu0797 | plu1566 | Unnamed protein product; Similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.921 |
hisA2 | hisB | plu0797 | plu1568 | Unnamed protein product; Similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol-phosphatase/imisazoleglycerol- phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | 0.987 |
hisA2 | hisD | plu0797 | plu1569 | Unnamed protein product; Similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.989 |
hisA2 | hisF | plu0797 | plu1565 | Unnamed protein product; Similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit HisF (IGP synthase cyclase subunit); IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisF subunit catalyzes the cyclization activity that produces IGP and AICAR from PRFAR using the ammonia provided by the HisH subunit. | 0.996 |
hisA2 | hisG | plu0797 | plu1570 | Unnamed protein product; Similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | ATP phosphoribosyltransferase; Catalyzes the condensation of ATP and 5-phosphoribose 1- diphosphate to form N'-(5'-phosphoribosyl)-ATP (PR-ATP). Has a crucial role in the pathway because the rate of histidine biosynthesis seems to be controlled primarily by regulation of HisG enzymatic activity. | 0.926 |
hisA2 | hisH | plu0797 | plu1567 | Unnamed protein product; Similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Imidazole glycerol phosphate synthase subunit HisH; IGPS catalyzes the conversion of PRFAR and glutamine to IGP, AICAR and glutamate. The HisH subunit catalyzes the hydrolysis of glutamine to glutamate and ammonia as part of the synthesis of IGP and AICAR. The resulting ammonia molecule is channeled to the active site of HisF. | 0.994 |
hisA2 | hisI | plu0797 | plu1564 | Unnamed protein product; Similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | phosphoribosyl-AMP cyclohydrolase (PRA-CH) / phosphoribosyl-ATP pyrophosphatase (PRA-PH); In the C-terminal section; belongs to the PRA-PH family. | 0.999 |
hisA2 | metL | plu0797 | plu4755 | Unnamed protein product; Similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; homoserine dehydrogenase II]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.553 |
hisA2 | thrA | plu0797 | plu0563 | Unnamed protein product; Similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | Aspartokinase I-homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.553 |
hisB | hisA | plu1568 | plu1566 | Histidinol-phosphatase/imisazoleglycerol- phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.997 |
hisB | hisA2 | plu1568 | plu0797 | Histidinol-phosphatase/imisazoleglycerol- phosphate dehydratase; In the C-terminal section; belongs to the imidazoleglycerol-phosphate dehydratase family. | Unnamed protein product; Similar to phosphoribosylformimino-5-aminoimidazole carboxamide ribotide isomerase. | 0.987 |