Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
macAMacrolide-specific efflux protein MacA precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family. (370 aa)    
Predicted Functional Partners:
macB
Macrolide-specific ABC-type efflux carrier protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
 
 
 0.959
plu2736
Unnamed protein product; Similar to ABC transporter (permease subunit).
 
 
 0.839
plu2647
Unnamed protein product; Highly similar to permease of ABC transporter.
 
 
 0.832
acrB
Acriflavin resistance protein B.
 
 
 0.742
prtD
Outer membrane protein PrtD.
  
 0.699
tolC
Outer membrane protein precursor TolC.
  
 0.699
plu0759
HlyD_D23 domain-containing protein; Unnamed protein product; Some similarities with multidrug efflux membrane fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
  
  0.678
plu0758
Unnamed protein product; Similar to multidrug efflux transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
 
 0.657
plu2734
HlyD_D23 domain-containing protein; Unnamed protein product; Membrane fusion protein (MPF) component of efflux system; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
  
 
0.635
mdtA
Multidrug resistance protein MdtA; Unnamed protein product; Similar to putative membrane protein YegM of Escherichia coli; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
  
 
0.597
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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