Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
putADelta-1-pyrroline-5-carboxylate dehydrogenase; Oxidizes proline to glutamate for use as a carbon and nitrogen source; Belongs to the aldehyde dehydrogenase family. In the N-terminal section; belongs to the proline dehydrogenase family. (1326 aa)    
Predicted Functional Partners:
proC
Pyrroline-5-carboxylate reductase (P5CR) (P5C reductase); Catalyzes the reduction of 1-pyrroline-5-carboxylate (PCA) to L-proline.
   
 0.969
gdhA
NADP-specific glutamate dehydrogenase (NADP-GDH); Belongs to the Glu/Leu/Phe/Val dehydrogenases family.
  
 
 0.961
gltB
Glutamate synthase [NADPH] large chain precursor (glutamate synthase alpha subunit) (NADPH-GOGAT) (GLTS alpha chain).
  
 
 0.956
proA
Gamma-glutamyl phosphate reductase (GPR) (glutamate-5-semialdehyde dehydrogenase); Catalyzes the NADPH-dependent reduction of L-glutamate 5- phosphate into L-glutamate 5-semialdehyde and phosphate. The product spontaneously undergoes cyclization to form 1-pyrroline-5-carboxylate. Belongs to the gamma-glutamyl phosphate reductase family.
    
 0.955
proB
Glutamate 5-kinase (gamma-glutamyl kinase) (GK); Catalyzes the transfer of a phosphate group to glutamate to form L-glutamate 5-phosphate.
    
 0.952
putP
Sodium/proline symporter (Proline permease); Catalyzes the sodium-dependent uptake of extracellular L- proline; Belongs to the sodium:solute symporter (SSF) (TC 2.A.21) family.
  
  
 0.952
glnA
Glutamine synthetase (glutamate--ammonia ligase).
   
 
 0.951
plu0762
Unnamed protein product; Some similarities with acyl-Coenzyme A dehydrogenase.
     
 0.914
glsA
Glutaminase; Unnamed protein product; Highly similar to probable glutaminase YneH of Escherichia coli; Belongs to the glutaminase family.
   
 
 0.908
pip
Proline iminopeptidase (PIP); Belongs to the peptidase S33 family.
     
 0.904
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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