| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| bioA | bioB | plu1484 | plu1485 | Adenosylmethionine--8-amino-7-oxononanoate transaminase (DAPA aminotransferase); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Biotin synthetase (biotin synthase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 0.995 |
| bioA | bioC | plu1484 | plu1487 | Adenosylmethionine--8-amino-7-oxononanoate transaminase (DAPA aminotransferase); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Biotin synthesis protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.738 |
| bioA | bioD | plu1484 | plu1488 | Adenosylmethionine--8-amino-7-oxononanoate transaminase (DAPA aminotransferase); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Dethiobiotin synthetase (dethiobiotin synthase) (DTB synthetase) (DTBS); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.997 |
| bioA | bioD-2 | plu1484 | plu2227 | Adenosylmethionine--8-amino-7-oxononanoate transaminase (DAPA aminotransferase); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | ATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.995 |
| bioA | bioF | plu1484 | plu1486 | Adenosylmethionine--8-amino-7-oxononanoate transaminase (DAPA aminotransferase); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 7-keto-8-amino pelargonic acid synthetase (8-amino-7-oxononanoate synthase); Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.995 |
| bioA | birA | plu1484 | plu4732 | Adenosylmethionine--8-amino-7-oxononanoate transaminase (DAPA aminotransferase); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.836 |
| bioA | kbl | plu1484 | plu4846 | Adenosylmethionine--8-amino-7-oxononanoate transaminase (DAPA aminotransferase); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.601 |
| bioA | plu1504 | plu1484 | plu1504 | Adenosylmethionine--8-amino-7-oxononanoate transaminase (DAPA aminotransferase); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Aminotran_1_2 domain-containing protein; Unnamed protein product; Some similarities with 2-amino-3-ketobutyrate coenzyme A ligase. | 0.652 |
| bioA | plu3565 | plu1484 | plu3565 | Adenosylmethionine--8-amino-7-oxononanoate transaminase (DAPA aminotransferase); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | Aminotran_1_2 domain-containing protein; Unnamed protein product; Similar to class II aminotransferase and 5-aminolevulinic acid synthase. | 0.963 |
| bioB | bioA | plu1485 | plu1484 | Biotin synthetase (biotin synthase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Adenosylmethionine--8-amino-7-oxononanoate transaminase (DAPA aminotransferase); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.995 |
| bioB | bioC | plu1485 | plu1487 | Biotin synthetase (biotin synthase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Biotin synthesis protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | 0.974 |
| bioB | bioD | plu1485 | plu1488 | Biotin synthetase (biotin synthase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Dethiobiotin synthetase (dethiobiotin synthase) (DTB synthetase) (DTBS); Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.998 |
| bioB | bioD-2 | plu1485 | plu2227 | Biotin synthetase (biotin synthase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | ATP-dependent dethiobiotin synthetase BioD; Catalyzes a mechanistically unusual reaction, the ATP- dependent insertion of CO2 between the N7 and N8 nitrogen atoms of 7,8- diaminopelargonic acid (DAPA) to form an ureido ring. Belongs to the dethiobiotin synthetase family. | 0.997 |
| bioB | bioF | plu1485 | plu1486 | Biotin synthetase (biotin synthase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 7-keto-8-amino pelargonic acid synthetase (8-amino-7-oxononanoate synthase); Catalyzes the decarboxylative condensation of pimeloyl-[acyl- carrier protein] and L-alanine to produce 8-amino-7-oxononanoate (AON), [acyl-carrier protein], and carbon dioxide. | 0.981 |
| bioB | birA | plu1485 | plu4732 | Biotin synthetase (biotin synthase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | 0.986 |
| bioB | kbl | plu1485 | plu4846 | Biotin synthetase (biotin synthase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | 2-amino-3-ketobutyrate coenzyme A ligase (AKB ligase) (glycine acetyltransferase); Catalyzes the cleavage of 2-amino-3-ketobutyrate to glycine and acetyl-CoA. | 0.616 |
| bioB | plu1504 | plu1485 | plu1504 | Biotin synthetase (biotin synthase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Aminotran_1_2 domain-containing protein; Unnamed protein product; Some similarities with 2-amino-3-ketobutyrate coenzyme A ligase. | 0.678 |
| bioB | plu2260 | plu1485 | plu2260 | Biotin synthetase (biotin synthase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Unnamed protein product; Similar to beta-alanine--pyruvate transaminase; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. | 0.777 |
| bioB | plu3565 | plu1485 | plu3565 | Biotin synthetase (biotin synthase); Catalyzes the conversion of dethiobiotin (DTB) to biotin by the insertion of a sulfur atom into dethiobiotin via a radical-based mechanism; Belongs to the radical SAM superfamily. Biotin synthase family. | Aminotran_1_2 domain-containing protein; Unnamed protein product; Similar to class II aminotransferase and 5-aminolevulinic acid synthase. | 0.683 |
| bioC | bioA | plu1487 | plu1484 | Biotin synthesis protein; Converts the free carboxyl group of a malonyl-thioester to its methyl ester by transfer of a methyl group from S-adenosyl-L- methionine (SAM). It allows to synthesize pimeloyl-ACP via the fatty acid synthetic pathway. | Adenosylmethionine--8-amino-7-oxononanoate transaminase (DAPA aminotransferase); Catalyzes the transfer of the alpha-amino group from S- adenosyl-L-methionine (SAM) to 7-keto-8-aminopelargonic acid (KAPA) to form 7,8-diaminopelargonic acid (DAPA). It is the only animotransferase known to utilize SAM as an amino donor; Belongs to the class-III pyridoxal-phosphate-dependent aminotransferase family. BioA subfamily. | 0.738 |
