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Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
plu2259Unnamed protein product; Similar to unknown protein. (803 aa)    
Predicted Functional Partners:
ilvH
Acetolactate synthase isozyme III small subunit (AHAS-III) (acetohydroxy-acid synthase III small subunit) (ALS-III).
  
 
 0.848
gltB
Glutamate synthase [NADPH] large chain precursor (glutamate synthase alpha subunit) (NADPH-GOGAT) (GLTS alpha chain).
     
 0.704
plu2321
Unnamed protein product; Similar to protein HMWP1 of Yersinia enterocolitica.
  
 0.609
ilvC
Ketol-acid reductoisomerase (NADP(+)); Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
  
  
 0.606
thrA
Aspartokinase I-homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
  
 0.568
metL
Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; homoserine dehydrogenase II]; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
  
 0.568
ilvD
Dihydroxy-acid dehydratase (DAD); Belongs to the IlvD/Edd family.
  
 
 0.538
maeB
NADP-dependent malic enzyme (NADP-ME).
  
 
 0.494
hisD
Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine.
  
  
 0.465
katE
Catalase; Belongs to the catalase family.
   
 0.430
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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