STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
plu2452Pseudouridine synthase; Unnamed protein product; Highly similar to probable pseudouridylate synthase YciL of Escherichia coli; Belongs to the pseudouridine synthase RsuA family. (310 aa)    
Predicted Functional Partners:
engA
GTP-binding protein EngA; GTPase that plays an essential role in the late steps of ribosome biogenesis; Belongs to the TRAFAC class TrmE-Era-EngA-EngB-Septin-like GTPase superfamily. EngA (Der) GTPase family.
 
  
 0.851
mssA
Cytidylate kinase (CK) (cytidine monophosphate kinase) (CMP kinase) (MssA protein) (P25).
  
 0.755
xthA
Exodeoxyribonuclease III (exonuclease III) (EXO III) (AP endonuclease VI).
  
    0.649
rlmL
Ribosomal RNA large subunit methyltransferase K/L; Specifically methylates the guanine in position 2445 (m2G2445) and the guanine in position 2069 (m7G2069) of 23S rRNA. Belongs to the methyltransferase superfamily. RlmKL family.
  
 
 0.533
rluC
Ribosomal large subunit pseudouridine synthase C (pseudouridylate synthase) (uracil hydrolyase); Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
 
 
 
 0.474
rlmN
Dual-specificity RNA methyltransferase RlmN; Specifically methylates position 2 of adenine 2503 in 23S rRNA and position 2 of adenine 37 in tRNAs. m2A2503 modification seems to play a crucial role in the proofreading step occurring at the peptidyl transferase center and thus would serve to optimize ribosomal fidelity; Belongs to the radical SAM superfamily. RlmN family.
 
  
 0.458
yjjK
ATP-binding protein YjjK.
 
    0.453
rluD
Ribosomal large subunit pseudouridine synthase D (pseudouridylate synthase) (uracil hydrolyase); Responsible for synthesis of pseudouridine from uracil. Belongs to the pseudouridine synthase RluA family.
 
 
 
 0.430
era
GTP-binding protein era; An essential GTPase that binds both GDP and GTP, with rapid nucleotide exchange. Plays a role in 16S rRNA processing and 30S ribosomal subunit biogenesis and possibly also in cell cycle regulation and energy metabolism.
 
    0.418
ychF
Ribosome-binding ATPase YchF; ATPase that binds to both the 70S ribosome and the 50S ribosomal subunit in a nucleotide-independent manner.
 
  
 0.413
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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