| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| glyA | plu3563 | plu3291 | plu3563 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Glutamine amidotransferase type-1 domain-containing protein; Unnamed protein product; Similar to p-aminobenzoic acid synthase. | 0.498 |
| glyA | trpA | plu3291 | plu2467 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.924 |
| glyA | trpB | plu3291 | plu2466 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.920 |
| glyA | trpE | plu3291 | plu2462 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Anthranilate synthase component I. | 0.595 |
| hisD | plu3563 | plu1569 | plu3563 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | Glutamine amidotransferase type-1 domain-containing protein; Unnamed protein product; Similar to p-aminobenzoic acid synthase. | 0.738 |
| hisD | trpA | plu1569 | plu2467 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.928 |
| hisD | trpB | plu1569 | plu2466 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.839 |
| hisD | trpC | plu1569 | plu2465 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | Tryptophan biosynthesis protein TrpCF [includes: indole-3-glycerol phosphate synthase (IGPS); N-(5'-phospho-ribosyl)anthrnilate isomerase (PRAI)]. | 0.877 |
| hisD | trpD | plu1569 | plu2464 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | Anthranilate synthase component II anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.889 |
| hisD | trpE | plu1569 | plu2462 | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | Anthranilate synthase component I. | 0.448 |
| pabA | plu3563 | plu0393 | plu3563 | Para-aminobenzoate synthase glutamine amidotransferase, component II. | Glutamine amidotransferase type-1 domain-containing protein; Unnamed protein product; Similar to p-aminobenzoic acid synthase. | 0.968 |
| pabA | trpA | plu0393 | plu2467 | Para-aminobenzoate synthase glutamine amidotransferase, component II. | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.926 |
| pabA | trpB | plu0393 | plu2466 | Para-aminobenzoate synthase glutamine amidotransferase, component II. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.923 |
| pabA | trpC | plu0393 | plu2465 | Para-aminobenzoate synthase glutamine amidotransferase, component II. | Tryptophan biosynthesis protein TrpCF [includes: indole-3-glycerol phosphate synthase (IGPS); N-(5'-phospho-ribosyl)anthrnilate isomerase (PRAI)]. | 0.998 |
| pabA | trpD | plu0393 | plu2464 | Para-aminobenzoate synthase glutamine amidotransferase, component II. | Anthranilate synthase component II anthranilate phosphoribosyltransferase; Catalyzes the transfer of the phosphoribosyl group of 5- phosphorylribose-1-pyrophosphate (PRPP) to anthranilate to yield N-(5'- phosphoribosyl)-anthranilate (PRA). | 0.993 |
| pabA | trpE | plu0393 | plu2462 | Para-aminobenzoate synthase glutamine amidotransferase, component II. | Anthranilate synthase component I. | 0.998 |
| pabA | trpG | plu0393 | plu2463 | Para-aminobenzoate synthase glutamine amidotransferase, component II. | Anthranilate synthase component II (Glutamine amido-transferase). | 0.824 |
| plu3563 | glyA | plu3563 | plu3291 | Glutamine amidotransferase type-1 domain-containing protein; Unnamed protein product; Similar to p-aminobenzoic acid synthase. | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.498 |
| plu3563 | hisD | plu3563 | plu1569 | Glutamine amidotransferase type-1 domain-containing protein; Unnamed protein product; Similar to p-aminobenzoic acid synthase. | Histidinol dehydrogenase; Catalyzes the sequential NAD-dependent oxidations of L- histidinol to L-histidinaldehyde and then to L-histidine. | 0.738 |
| plu3563 | pabA | plu3563 | plu0393 | Glutamine amidotransferase type-1 domain-containing protein; Unnamed protein product; Similar to p-aminobenzoic acid synthase. | Para-aminobenzoate synthase glutamine amidotransferase, component II. | 0.968 |
