Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
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Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
plu2552Unnamed protein product; Similar to putative nitroreductase YdjA of Escherichia coli. (183 aa)    
Predicted Functional Partners:
topB
DNA topoisomerase III; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA su [...]
 
   
 0.838
selD
Selenide, water dikinase (selenophosphate synthase) (selenium donnor protein); Synthesizes selenophosphate from selenide and ATP.
  
    0.830
plu1615
Unnamed protein product; Similar to unknown protein YcaO of Escherichia coli.
  
  
 0.766
birA
Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon.
  
    0.705
sppA
Protease IV (endopeptidase IV) (signal peptide peptidase).
     
 0.593
plu2262
Unnamed protein product; Some similarities with molybdopterin oxidoreductase and dimethylsulfoxide reductase; Belongs to the prokaryotic molybdopterin-containing oxidoreductase family.
  
  
 0.589
yadH
ABC transporter, integral membrane protein YadH.
  
  
 0.577
plu1472
Unnamed protein product; Similar to putative membrane protein.
  
  
 0.552
tadA
tRNA-specific adenosine deaminase; Catalyzes the deamination of adenosine to inosine at the wobble position 34 of tRNA(Arg2); Belongs to the cytidine and deoxycytidylate deaminase family.
  
  
 0.543
gltB
Glutamate synthase [NADPH] large chain precursor (glutamate synthase alpha subunit) (NADPH-GOGAT) (GLTS alpha chain).
     
 0.541
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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