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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
slyATranscriptional regulator protein SlyA; Transcription regulator that can specifically activate or repress expression of target genes. Regulates the cpm operon, which contains cpmA, cpmB, cpmC, cpmD, cpmE, cpmF, cpmG and cpmH, involved in carbapenem-like antibiotic production; Belongs to the SlyA family. (143 aa)    
Predicted Functional Partners:
ompR
Two-component response regulator.
      
 0.579
phoQ
Two-component sensor kinase PhoQ.
   
  
 0.579
luxS
Autoinducer-2 (AI-2) production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
   
  
 0.538
cpmA
CpmA protein involved in carbapenem biosynthesis.
     
 0.534
sctC
Type III secretion component protein SctC; Similar to Yop proteins translocation protein C.
      
 0.529
tciR2
TciR2 protein; Similar to LysR-type transcriptional activator; Belongs to the LysR transcriptional regulatory family.
   
  
 0.527
cpmH
CpmH protein, probably involved in carbapenem biosynthesis or resistance.
      
 0.526
xre
Antitoxin Xre; Antitoxin component of a type II toxin-antitoxin (TA) system. Neutralizes the NAD(+) depleting activity of cognate toxin Res.
      
 0.526
plu2787
HTH araC/xylS-type domain-containing protein; Unnamed protein product; Similar to AraC-family transcriptional regulatory protein.
  
  
 0.526
sctP
Type III secretion component protein SctP; Similar to Yop proteins translocation protein P.
      
 0.526
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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