| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| cysE | glyA | plu4837 | plu3291 | Serine acetyltransferase (SAT). | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.831 |
| cysE | ilvA | plu4837 | plu4681 | Serine acetyltransferase (SAT). | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.803 |
| cysE | plu0524 | plu4837 | plu0524 | Serine acetyltransferase (SAT). | Unnamed protein product; Similar to cystathionine beta-synthase. | 0.944 |
| cysE | plu2021 | plu4837 | plu2021 | Serine acetyltransferase (SAT). | Serine acetyltransferase; Unnamed protein product; Some similarities with serine O-acetyltransferase. | 0.929 |
| cysE | pssA | plu4837 | plu1271 | Serine acetyltransferase (SAT). | CDP-diacylglycerol--serine O-phosphatidyltransferase (phosphatidylserine synthase). | 0.822 |
| cysE | sdaA | plu4837 | plu2696 | Serine acetyltransferase (SAT). | L-serine dehydratase 1 (SDH 1); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.910 |
| cysE | serB | plu4837 | plu0551 | Serine acetyltransferase (SAT). | Phosphoserine phosphatase. | 0.832 |
| cysE | trpA | plu4837 | plu2467 | Serine acetyltransferase (SAT). | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.808 |
| cysE | trpB | plu4837 | plu2466 | Serine acetyltransferase (SAT). | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.807 |
| dsdA | ilvA | plu1970 | plu4681 | D-serine dehydratase DsdA. | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.906 |
| dsdA | sdaA | plu1970 | plu2696 | D-serine dehydratase DsdA. | L-serine dehydratase 1 (SDH 1); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.919 |
| glyA | cysE | plu3291 | plu4837 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine acetyltransferase (SAT). | 0.831 |
| glyA | ilvA | plu3291 | plu4681 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.915 |
| glyA | plu0524 | plu3291 | plu0524 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Unnamed protein product; Similar to cystathionine beta-synthase. | 0.939 |
| glyA | plu2021 | plu3291 | plu2021 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Serine acetyltransferase; Unnamed protein product; Some similarities with serine O-acetyltransferase. | 0.831 |
| glyA | pssA | plu3291 | plu1271 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | CDP-diacylglycerol--serine O-phosphatidyltransferase (phosphatidylserine synthase). | 0.920 |
| glyA | sdaA | plu3291 | plu2696 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | L-serine dehydratase 1 (SDH 1); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.960 |
| glyA | serB | plu3291 | plu0551 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Phosphoserine phosphatase. | 0.927 |
| glyA | trpA | plu3291 | plu2467 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family. | 0.932 |
| glyA | trpB | plu3291 | plu2466 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.927 |
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