Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
lpoBPenicillin-binding protein activator LpoB; Regulator of peptidoglycan synthesis that is essential for the function of penicillin-binding protein 1B (PBP1b). (189 aa)    
Predicted Functional Partners:
thiK
Thiamine kinase; Catalyzes the phosphorylation of thiamine to thiamine phosphate.
 
  
 0.898
mrcB
Penicillin-binding protein 1B; Cell wall formation. Synthesis of cross-linked peptidoglycan from the lipid intermediates. The enzyme has a penicillin-insensitive transglycosylase N-terminal domain (formation of linear glycan strands) and a penicillin-sensitive transpeptidase C-terminal domain (cross- linking of the peptide subunits).
  
 
 
 0.846
rof
Rof protein.
  
   
 0.801
ftsN
Cell division protein FtsN; Essential cell division protein that activates septal peptidoglycan synthesis and constriction of the cell. Acts on both sides of the membrane, via interaction with FtsA in the cytoplasm and interaction with the FtsQBL complex in the periplasm. These interactions may induce a conformational switch in both FtsA and FtsQBL, leading to septal peptidoglycan synthesis by FtsI and associated synthases.
  
   
 0.772
plu1752
Unnamed protein product; Highly similar to outer membrane protein N precursor (Porin OmpN); Belongs to the Gram-negative porin family.
  
     0.771
ompN
Outer membrane protein N precursor (Porin OmpN).
  
     0.769
helD
DNA helicase IV.
  
     0.768
plu2166
Unnamed protein product; Similar to unknown protein YdgH precursor of Escherichia coli.
  
     0.767
holD
DNA polymerase III, psi subunit; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity. The exact function of the psi subunit is unknown.
  
     0.766
plu0289
Unnamed protein product; Similar to putative lipoprotein YidQ precursor of Escherichia coli.
  
     0.762
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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