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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
rseASigma-E factor negative regulatory protein; An anti-sigma factor for extracytoplasmic function (ECF) sigma factor sigma-E (RpoE). ECF sigma factors are held in an inactive form by an anti-sigma factor until released by regulated intramembrane proteolysis (RIP). RIP occurs when an extracytoplasmic signal triggers a concerted proteolytic cascade to transmit information and elicit cellular responses. The membrane-spanning regulatory substrate protein is first cut periplasmically (site-1 protease, S1P, DegS), then within the membrane itself (site-2 protease, S2P, RseP), while cytoplasmic p [...] (216 aa)    
Predicted Functional Partners:
rseB
Sigma-E factor regulatory protein RseB precursor.
 
 
 0.983
rpoE
RNA polymerase sigma-E factor (sigma-24); Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.970
degS
Protease DegS; Truncated gene, similar to virulence-associated protein.
  
 
 0.846
lapA
Lipopolysaccharide assembly protein A; Involved in the assembly of lipopolysaccharide (LPS). Belongs to the LapA family.
  
     0.770
lptC
Lipopolysaccharide export system protein LptC; Involved in the assembly of lipopolysaccharide (LPS). Required for the translocation of LPS from the inner membrane to the outer membrane. Facilitates the transfer of LPS from the inner membrane to the periplasmic protein LptA. Could be a docking site for LptA. Belongs to the LptC family.
  
     0.755
nlpB
Lipoprotein-34 precursor; Part of the outer membrane protein assembly complex, which is involved in assembly and insertion of beta-barrel proteins into the outer membrane.
  
     0.754
plu0077
Unnamed protein product; Similar to transcription initiation factor sigma homolog; Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.751
plu0741
Unnamed protein product; Similar to probable sigma-70 factor, ECF subfamily.
  
 
 0.751
plu1235
Unnamed protein product; Similar to sigma-70 factor, ECF subfamily.
  
 
 0.751
fecI
RNA polymerase sigma factor; Truncated transposase, IS30 family (ISPlu1-p); Belongs to the sigma-70 factor family. ECF subfamily.
  
 
 0.751
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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