Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
prpC2-methylcitrate synthase (Methylcitrate synthase) (Citrate synthase 2); Belongs to the citrate synthase family. (388 aa)    
Predicted Functional Partners:
prpD
2-methylcitrate dehydratase.
 
 0.998
acnA
Aconitate hydratase 1 (citrate hydro-lyase 1) (aconitase 1); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
 
 0.989
mdh
Malate dehydrogenase; Catalyzes the reversible oxidation of malate to oxaloacetate.
  
 0.977
prpB
Probable methylisocitrate lyase (2-methylisocitrate lyase); Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
 
 
 0.968
prpE
Propionate--CoA ligase (Propionyl-CoA synthetase).
  
 0.961
acnB
Aconitate hydratase 2 (citrate hydro-lyase 2) (aconitase 2); Belongs to the aconitase/IPM isomerase family.
  
 
 0.953
aceF
Dihydrolipoamide acetyltransferase component of pyruvate dehydrogenase complex (E2); The pyruvate dehydrogenase complex catalyzes the overall conversion of pyruvate to acetyl-CoA and CO(2).
  
 0.949
aceB
Malate synthase A (MSA).
   
 0.945
fumC
Fumarate hydratase class II (fumarase); Involved in the TCA cycle. Catalyzes the stereospecific interconversion of fumarate to L-malate; Belongs to the class-II fumarase/aspartase family. Fumarase subfamily.
   
 0.934
pta
Phosphate acetyltransferase (phosphotransacetylase); Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
  
 
 0.930
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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