| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| aceB | acs | plu4396 | plu0074 | Malate synthase A (MSA). | Acetyl-coenzyme A synthetase (acetate--COA ligase) (acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 0.951 |
| aceB | adhE | plu4396 | plu2496 | Malate synthase A (MSA). | Aldehyde-alcohol dehydrogenase [includes: alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase [acetylating] (ACDH); pyruvate-formate-lyase deactivase (PFL deactivase)]; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.914 |
| aceB | plu4306 | plu4396 | plu4306 | Malate synthase A (MSA). | Unnamed protein product; Similar to biotin carboxylase. | 0.921 |
| aceB | prpB | plu4396 | plu3542 | Malate synthase A (MSA). | Probable methylisocitrate lyase (2-methylisocitrate lyase); Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.897 |
| aceB | prpC | plu4396 | plu3541 | Malate synthase A (MSA). | 2-methylcitrate synthase (Methylcitrate synthase) (Citrate synthase 2); Belongs to the citrate synthase family. | 0.505 |
| aceB | sucC | plu4396 | plu1432 | Malate synthase A (MSA). | succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.838 |
| aceB | sucD | plu4396 | plu1433 | Malate synthase A (MSA). | succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.861 |
| acnB | frdA | plu3619 | plu4124 | Aconitate hydratase 2 (citrate hydro-lyase 2) (aconitase 2); Belongs to the aconitase/IPM isomerase family. | Fumarate reductase flavoprotein subunit. | 0.534 |
| acnB | prpB | plu3619 | plu3542 | Aconitate hydratase 2 (citrate hydro-lyase 2) (aconitase 2); Belongs to the aconitase/IPM isomerase family. | Probable methylisocitrate lyase (2-methylisocitrate lyase); Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.915 |
| acnB | prpC | plu3619 | plu3541 | Aconitate hydratase 2 (citrate hydro-lyase 2) (aconitase 2); Belongs to the aconitase/IPM isomerase family. | 2-methylcitrate synthase (Methylcitrate synthase) (Citrate synthase 2); Belongs to the citrate synthase family. | 0.618 |
| acnB | prpD | plu3619 | plu3540 | Aconitate hydratase 2 (citrate hydro-lyase 2) (aconitase 2); Belongs to the aconitase/IPM isomerase family. | 2-methylcitrate dehydratase. | 0.917 |
| acnB | sucC | plu3619 | plu1432 | Aconitate hydratase 2 (citrate hydro-lyase 2) (aconitase 2); Belongs to the aconitase/IPM isomerase family. | succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.773 |
| acnB | sucD | plu3619 | plu1433 | Aconitate hydratase 2 (citrate hydro-lyase 2) (aconitase 2); Belongs to the aconitase/IPM isomerase family. | succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.612 |
| acs | aceB | plu0074 | plu4396 | Acetyl-coenzyme A synthetase (acetate--COA ligase) (acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Malate synthase A (MSA). | 0.951 |
| acs | adhE | plu0074 | plu2496 | Acetyl-coenzyme A synthetase (acetate--COA ligase) (acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Aldehyde-alcohol dehydrogenase [includes: alcohol dehydrogenase (ADH) and acetaldehyde dehydrogenase [acetylating] (ACDH); pyruvate-formate-lyase deactivase (PFL deactivase)]; In the C-terminal section; belongs to the iron-containing alcohol dehydrogenase family. | 0.942 |
| acs | plu4306 | plu0074 | plu4306 | Acetyl-coenzyme A synthetase (acetate--COA ligase) (acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Unnamed protein product; Similar to biotin carboxylase. | 0.919 |
| acs | prpB | plu0074 | plu3542 | Acetyl-coenzyme A synthetase (acetate--COA ligase) (acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | Probable methylisocitrate lyase (2-methylisocitrate lyase); Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family. | 0.865 |
| acs | prpC | plu0074 | plu3541 | Acetyl-coenzyme A synthetase (acetate--COA ligase) (acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | 2-methylcitrate synthase (Methylcitrate synthase) (Citrate synthase 2); Belongs to the citrate synthase family. | 0.949 |
| acs | sucC | plu0074 | plu1432 | Acetyl-coenzyme A synthetase (acetate--COA ligase) (acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit. | 0.859 |
| acs | sucD | plu0074 | plu1433 | Acetyl-coenzyme A synthetase (acetate--COA ligase) (acyl-activating enzyme); Catalyzes the conversion of acetate into acetyl-CoA (AcCoA), an essential intermediate at the junction of anabolic and catabolic pathways. Acs undergoes a two-step reaction. In the first half reaction, Acs combines acetate with ATP to form acetyl-adenylate (AcAMP) intermediate. In the second half reaction, it can then transfer the acetyl group from AcAMP to the sulfhydryl group of CoA, forming the product AcCoA. | succinyl-CoA synthetase alpha chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The alpha subunit of the enzyme binds the substrates coenzyme A and phosphate, while succinate binding and nucleotide specificity is provided by the beta subunit. | 0.853 |
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