Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
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empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
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Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
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Assay-based Predictions
experimentally determined
co-expression
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gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
acnBAconitate hydratase 2 (citrate hydro-lyase 2) (aconitase 2); Belongs to the aconitase/IPM isomerase family. (865 aa)    
Predicted Functional Partners:
icd
Isocitrate dehydrogenase [NADP].
  
 
 0.982
acnA
Aconitate hydratase 1 (citrate hydro-lyase 1) (aconitase 1); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
    
 0.954
gltA
Citrate synthase; Belongs to the citrate synthase family.
  
 
 0.953
plu3138
Citrate synthase; Unnamed protein product; Weakly similar to citrate synthase.
  
 
 0.953
prpC
2-methylcitrate synthase (Methylcitrate synthase) (Citrate synthase 2); Belongs to the citrate synthase family.
  
 
 0.953
prpD
2-methylcitrate dehydratase.
     
 0.926
aceA
Isocitrate lyase (isocitrase) (isocitratase) (ICL).
   
 
 0.926
sucA
2-oxoglutarate dehydrogenase E1 component (Alpha-ketoglutarate dehydrogenase).
   
  
 0.911
prpB
Probable methylisocitrate lyase (2-methylisocitrate lyase); Catalyzes the thermodynamically favored C-C bond cleavage of (2R,3S)-2-methylisocitrate to yield pyruvate and succinate. Belongs to the isocitrate lyase/PEP mutase superfamily. Methylisocitrate lyase family.
   
 
 0.910
sucC
succinyl-CoA synthetase beta chain; Succinyl-CoA synthetase functions in the citric acid cycle (TCA), coupling the hydrolysis of succinyl-CoA to the synthesis of either ATP or GTP and thus represents the only step of substrate-level phosphorylation in the TCA. The beta subunit provides nucleotide specificity of the enzyme and binds the substrate succinate, while the binding sites for coenzyme A and phosphate are found in the alpha subunit.
  
  
 0.909
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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