| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ilvA | ilvG | plu4681 | plu4685 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase isozyme II large subunit (AHAS-II) (acetohydroxy-acid synthase II large subunit) (ALS-II). | 0.963 |
| ilvA | ilvH | plu4681 | plu3665 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase isozyme III small subunit (AHAS-III) (acetohydroxy-acid synthase III small subunit) (ALS-III). | 0.969 |
| ilvA | ilvI | plu4681 | plu3666 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase isozyme III large subunit (AHAS-III) (acetohydroxy-acid synthase III large subunit) (ALS-III). | 0.937 |
| ilvA | ilvM | plu4681 | plu4684 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Acetolactate synthase isozyme II small subunit (AHAS-II) (acetohydroxy-acid synthase II small subunit) (ALS-II). | 0.956 |
| ilvA | leuB | plu4681 | plu3674 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-isopropylmalate dehydrogenase (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.943 |
| ilvA | leuC | plu4681 | plu3675 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.517 |
| ilvA | leuD | plu4681 | plu3676 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.571 |
| ilvG | ilvA | plu4685 | plu4681 | Acetolactate synthase isozyme II large subunit (AHAS-II) (acetohydroxy-acid synthase II large subunit) (ALS-II). | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.963 |
| ilvG | ilvH | plu4685 | plu3665 | Acetolactate synthase isozyme II large subunit (AHAS-II) (acetohydroxy-acid synthase II large subunit) (ALS-II). | Acetolactate synthase isozyme III small subunit (AHAS-III) (acetohydroxy-acid synthase III small subunit) (ALS-III). | 0.998 |
| ilvG | ilvI | plu4685 | plu3666 | Acetolactate synthase isozyme II large subunit (AHAS-II) (acetohydroxy-acid synthase II large subunit) (ALS-II). | Acetolactate synthase isozyme III large subunit (AHAS-III) (acetohydroxy-acid synthase III large subunit) (ALS-III). | 0.911 |
| ilvG | ilvM | plu4685 | plu4684 | Acetolactate synthase isozyme II large subunit (AHAS-II) (acetohydroxy-acid synthase II large subunit) (ALS-II). | Acetolactate synthase isozyme II small subunit (AHAS-II) (acetohydroxy-acid synthase II small subunit) (ALS-II). | 0.992 |
| ilvG | leuA | plu4685 | plu3673 | Acetolactate synthase isozyme II large subunit (AHAS-II) (acetohydroxy-acid synthase II large subunit) (ALS-II). | 2-isopropylmalate synthase (alpha-isopropylmalate synthase) (alpha-IPM synthetase); Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily. | 0.963 |
| ilvG | leuB | plu4685 | plu3674 | Acetolactate synthase isozyme II large subunit (AHAS-II) (acetohydroxy-acid synthase II large subunit) (ALS-II). | 3-isopropylmalate dehydrogenase (beta-IPM dehydrogenase) (IMDH) (3-IPM-DH); Catalyzes the oxidation of 3-carboxy-2-hydroxy-4- methylpentanoate (3-isopropylmalate) to 3-carboxy-4-methyl-2- oxopentanoate. The product decarboxylates to 4-methyl-2 oxopentanoate. Belongs to the isocitrate and isopropylmalate dehydrogenases family. LeuB type 1 subfamily. | 0.980 |
| ilvG | leuC | plu4685 | plu3675 | Acetolactate synthase isozyme II large subunit (AHAS-II) (acetohydroxy-acid synthase II large subunit) (ALS-II). | 3-isopropylmalate dehydratase large subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. | 0.732 |
| ilvG | leuD | plu4685 | plu3676 | Acetolactate synthase isozyme II large subunit (AHAS-II) (acetohydroxy-acid synthase II large subunit) (ALS-II). | 3-isopropylmalate dehydratase small subunit; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the LeuD family. LeuD type 1 subfamily. | 0.727 |
| ilvG | plu1869 | plu4685 | plu1869 | Acetolactate synthase isozyme II large subunit (AHAS-II) (acetohydroxy-acid synthase II large subunit) (ALS-II). | 3-isopropylmalate dehydratase; Catalyzes the isomerization between 2-isopropylmalate and 3- isopropylmalate, via the formation of 2-isopropylmaleate. Belongs to the aconitase/IPM isomerase family. | 0.795 |
| ilvG | plu1870 | plu4685 | plu1870 | Acetolactate synthase isozyme II large subunit (AHAS-II) (acetohydroxy-acid synthase II large subunit) (ALS-II). | Aconitase_C domain-containing protein; Unnamed protein product; Similar to 3-isopropylmalate dehydratase, small subunit (leuD-2); Belongs to the LeuD family. | 0.707 |
| ilvH | ilvA | plu3665 | plu4681 | Acetolactate synthase isozyme III small subunit (AHAS-III) (acetohydroxy-acid synthase III small subunit) (ALS-III). | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.969 |
| ilvH | ilvG | plu3665 | plu4685 | Acetolactate synthase isozyme III small subunit (AHAS-III) (acetohydroxy-acid synthase III small subunit) (ALS-III). | Acetolactate synthase isozyme II large subunit (AHAS-II) (acetohydroxy-acid synthase II large subunit) (ALS-II). | 0.998 |
| ilvH | ilvI | plu3665 | plu3666 | Acetolactate synthase isozyme III small subunit (AHAS-III) (acetohydroxy-acid synthase III small subunit) (ALS-III). | Acetolactate synthase isozyme III large subunit (AHAS-III) (acetohydroxy-acid synthase III large subunit) (ALS-III). | 0.999 |
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