| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| dcm | metK | plu0338 | plu3683 | DNA-cytosine methyltransferase. | S-adenosylmethionine synthetase (methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.915 |
| dcm | plu0600 | plu0338 | plu0600 | DNA-cytosine methyltransferase. | Unnamed protein product; Weakly similar to site-specific DNA-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.928 |
| dcm | speD | plu0338 | plu0842 | DNA-cytosine methyltransferase. | S-adenosylmethionine decarboxylase proenzyme; Catalyzes the decarboxylation of S-adenosylmethionine to S- adenosylmethioninamine (dcAdoMet), the propylamine donor required for the synthesis of the polyamines spermine and spermidine from the diamine putrescine; Belongs to the prokaryotic AdoMetDC family. Type 2 subfamily. | 0.900 |
| glyA | metE | plu3291 | plu4420 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.572 |
| glyA | metF | plu3291 | plu4754 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 5,10-methylenetetrahydrofolate reductase; Truncated gene. Similar to the N-terminal region of transposase, IS630 family (ISPlu3-p); Belongs to the methylenetetrahydrofolate reductase family. | 0.959 |
| glyA | metK | plu3291 | plu3683 | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | S-adenosylmethionine synthetase (methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.789 |
| metE | glyA | plu4420 | plu3291 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.572 |
| metE | metF | plu4420 | plu4754 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 5,10-methylenetetrahydrofolate reductase; Truncated gene. Similar to the N-terminal region of transposase, IS630 family (ISPlu3-p); Belongs to the methylenetetrahydrofolate reductase family. | 0.955 |
| metE | metK | plu4420 | plu3683 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | S-adenosylmethionine synthetase (methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.979 |
| metE | plu2684 | plu4420 | plu2684 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | GAF domain-containing protein; Unnamed protein product; Similar to probable membrane protein YebR of Escherichia coli. | 0.900 |
| metE | plu3517 | plu4420 | plu3517 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Unnamed protein product; Highly similar to homocysteine synthase. | 0.930 |
| metE | tyrB | plu4420 | plu4357 | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | Aromatic-amino-acid aminotransferase (AROAT) (ARAT). | 0.902 |
| metF | glyA | plu4754 | plu3291 | 5,10-methylenetetrahydrofolate reductase; Truncated gene. Similar to the N-terminal region of transposase, IS630 family (ISPlu3-p); Belongs to the methylenetetrahydrofolate reductase family. | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.959 |
| metF | metE | plu4754 | plu4420 | 5,10-methylenetetrahydrofolate reductase; Truncated gene. Similar to the N-terminal region of transposase, IS630 family (ISPlu3-p); Belongs to the methylenetetrahydrofolate reductase family. | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.955 |
| metF | metK | plu4754 | plu3683 | 5,10-methylenetetrahydrofolate reductase; Truncated gene. Similar to the N-terminal region of transposase, IS630 family (ISPlu3-p); Belongs to the methylenetetrahydrofolate reductase family. | S-adenosylmethionine synthetase (methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 0.827 |
| metK | dcm | plu3683 | plu0338 | S-adenosylmethionine synthetase (methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | DNA-cytosine methyltransferase. | 0.915 |
| metK | glyA | plu3683 | plu3291 | S-adenosylmethionine synthetase (methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Serine hydroxymethyltransferase (serine methylase) (SHMT); Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.789 |
| metK | metE | plu3683 | plu4420 | S-adenosylmethionine synthetase (methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. | 0.979 |
| metK | metF | plu3683 | plu4754 | S-adenosylmethionine synthetase (methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | 5,10-methylenetetrahydrofolate reductase; Truncated gene. Similar to the N-terminal region of transposase, IS630 family (ISPlu3-p); Belongs to the methylenetetrahydrofolate reductase family. | 0.827 |
| metK | plu0600 | plu3683 | plu0600 | S-adenosylmethionine synthetase (methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme. | Unnamed protein product; Weakly similar to site-specific DNA-methyltransferase; Belongs to the class I-like SAM-binding methyltransferase superfamily. C5-methyltransferase family. | 0.915 |
