| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| adk | plu3848 | plu3836 | plu3848 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | Unnamed protein product; Similar to hypothetical proteins. Putative transmembrane protein. | 0.516 |
| adk | truA | plu3836 | plu3173 | Adenylate kinase (ATP-AMP transphosphorylase); Catalyzes the reversible transfer of the terminal phosphate group between ATP and AMP. Plays an important role in cellular energy homeostasis and in adenine nucleotide metabolism; Belongs to the adenylate kinase family. | tRNA pseudouridine synthase A; Formation of pseudouridine at positions 38, 39 and 40 in the anticodon stem and loop of transfer RNAs. | 0.406 |
| birA | cysG | plu4732 | plu0708 | Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.478 |
| birA | plu3847 | plu4732 | plu3847 | Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Biotin transporter; Unnamed protein product; Similar to biotin synthase. | 0.582 |
| birA | plu3848 | plu4732 | plu3848 | Bifunctional protein [Includes: biotin operon repressor; Acts both as a biotin--[acetyl-CoA-carboxylase] ligase and a biotin-operon repressor. In the presence of ATP, BirA activates biotin to form the BirA-biotinyl-5'-adenylate (BirA-bio-5'-AMP or holoBirA) complex. HoloBirA can either transfer the biotinyl moiety to the biotin carboxyl carrier protein (BCCP) subunit of acetyl-CoA carboxylase, or bind to the biotin operator site and inhibit transcription of the operon. | Unnamed protein product; Similar to hypothetical proteins. Putative transmembrane protein. | 0.428 |
| cbiC | cbiD | plu2997 | plu2996 | Precorrin-8X methylmutase (Precorrin isomerase). | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.987 |
| cbiC | cbiG | plu2997 | plu2992 | Precorrin-8X methylmutase (Precorrin isomerase). | Cobalamin biosynthesis protein G (CbiG). | 0.988 |
| cbiC | cysG | plu2997 | plu0708 | Precorrin-8X methylmutase (Precorrin isomerase). | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.481 |
| cbiC | plu3848 | plu2997 | plu3848 | Precorrin-8X methylmutase (Precorrin isomerase). | Unnamed protein product; Similar to hypothetical proteins. Putative transmembrane protein. | 0.407 |
| cbiC | plu3849 | plu2997 | plu3849 | Precorrin-8X methylmutase (Precorrin isomerase). | Putative ABC transporter ATP-binding protein plu3849; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). | 0.450 |
| cbiD | cbiC | plu2996 | plu2997 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Precorrin-8X methylmutase (Precorrin isomerase). | 0.987 |
| cbiD | cbiG | plu2996 | plu2992 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Cobalamin biosynthesis protein G (CbiG). | 0.998 |
| cbiD | cysG | plu2996 | plu0708 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.481 |
| cbiD | plu3848 | plu2996 | plu3848 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Unnamed protein product; Similar to hypothetical proteins. Putative transmembrane protein. | 0.416 |
| cbiD | plu3849 | plu2996 | plu3849 | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | Putative ABC transporter ATP-binding protein plu3849; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). | 0.465 |
| cbiG | cbiC | plu2992 | plu2997 | Cobalamin biosynthesis protein G (CbiG). | Precorrin-8X methylmutase (Precorrin isomerase). | 0.988 |
| cbiG | cbiD | plu2992 | plu2996 | Cobalamin biosynthesis protein G (CbiG). | Cobalamin biosynthesis protein CbiD; Catalyzes the methylation of C-1 in cobalt-precorrin-5B to form cobalt-precorrin-6A. | 0.998 |
| cbiG | cysG | plu2992 | plu0708 | Cobalamin biosynthesis protein G (CbiG). | Sirohaem synthase; Multifunctional enzyme that catalyzes the SAM-dependent methylations of uroporphyrinogen III at position C-2 and C-7 to form precorrin-2 via precorrin-1. Then it catalyzes the NAD-dependent ring dehydrogenation of precorrin-2 to yield sirohydrochlorin. Finally, it catalyzes the ferrochelation of sirohydrochlorin to yield siroheme. | 0.541 |
| cbiG | plu3848 | plu2992 | plu3848 | Cobalamin biosynthesis protein G (CbiG). | Unnamed protein product; Similar to hypothetical proteins. Putative transmembrane protein. | 0.527 |
| cbiG | plu3849 | plu2992 | plu3849 | Cobalamin biosynthesis protein G (CbiG). | Putative ABC transporter ATP-binding protein plu3849; Probably part of an ABC transporter complex. Responsible for energy coupling to the transport system (By similarity). | 0.430 |