Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
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colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
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[Homology]
Score
plu3917DHO_dh domain-containing protein; Catalyzes the conversion of dihydroorotate to orotate. (289 aa)    
Predicted Functional Partners:
pyrE
Orotate phosphoribosyltransferase (OPRT) (OPRTASE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
  
 0.978
pyrC
Dihydroorotase (DHOase); Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate.
  
 
 0.974
pyrD
Dihydroorotate dehydrogenase (dihydroorotate oxidase) (dhodehase) (dhodase) (dhod); Catalyzes the conversion of dihydroorotate to orotate with quinone as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 2 subfamily.
     
  0.900
fre
NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase).
  
 
 0.890
pyrB
Aspartate carbamoyltransferase catalytic chain (aspartate transcarbamylase) (ATCase); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family.
 
  
 0.839
pyrF
Orotidine-5'-phosphate decarboxylase (OMP decarboxylase); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
 
  
 0.822
carB
Carbamoylphosphate synthetase large subunit; Belongs to the CarB family.
 
 
 0.821
carA
Carbamoyl-phosphate synthase (glutamine-hydrolyzing); Belongs to the CarA family.
 
  
 0.809
plu3916
Unnamed protein product; Similar to creatininase (creatinine amidohydrolase).
       0.784
guaA
GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.
 
 
 0.760
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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