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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
tolCOuter membrane protein precursor TolC. (457 aa)    
Predicted Functional Partners:
acrA
Acriflavin resistance protein A precursor; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 0.974
plu0758
Unnamed protein product; Similar to multidrug efflux transporter; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family.
 
 0.973
acrB
Acriflavin resistance protein B.
  
 0.968
plu0759
HlyD_D23 domain-containing protein; Unnamed protein product; Some similarities with multidrug efflux membrane fusion protein; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
 
 0.952
macB
Macrolide-specific ABC-type efflux carrier protein MacB; Part of the tripartite efflux system MacAB-TolC. MacB is a non-canonical ABC transporter that contains transmembrane domains (TMD), which form a pore in the inner membrane, and an ATP-binding domain (NBD), which is responsible for energy generation. Confers resistance against macrolides.
  
 
 0.796
icc
Icc protein; Hydrolyzes cAMP to 5'-AMP. Plays an important regulatory role in modulating the intracellular concentration of cAMP, thereby influencing cAMP-dependent processes.
     0.758
mdtA
Multidrug resistance protein MdtA; Unnamed protein product; Similar to putative membrane protein YegM of Escherichia coli; Belongs to the membrane fusion protein (MFP) (TC 8.A.1) family.
  
 
 0.716
plu3351
Unnamed protein product; Some similarities with hemolysin secretion protein HlyD of Escherichia coli.
  
 
 0.716
tolB
TolB protein precursor; Part of the Tol-Pal system, which plays a role in outer membrane invagination during cell division and is important for maintaining outer membrane integrity. TolB occupies a key intermediary position in the Tol-Pal system because it communicates directly with both membrane-embedded components, Pal in the outer membrane and TolA in the inner membrane.
  
 
 
 0.697
mdtB
Multidrug resistance protein MdtB; Unnamed protein product; Highly similar to unknown protein YegN of Escherichia coli, putative acriflavin resistance protein D; Belongs to the resistance-nodulation-cell division (RND) (TC 2.A.6) family. MdtB subfamily.
  
 
 0.687
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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