prfC protein (Photorhabdus laumondii) - STRING interaction network

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prfC

Peptide chain release factor 3 (RF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily. (529 aa)

Predicted Functional Partners:

rpmA

0.820

prfA

0.788

rimI

0.736

rpmG

0.722

rplM

0.710

guaA

0.707

rplT

0.696

rplS

0.687

rpsJ

0.684

rplL

0.683

Your Current Organism:

Photorhabdus laumondii

NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1

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Browse interactions in tabular form:

node1	node2	node1 accession	node2 accession	node1 annotation	node2 annotation	score
guaA	prfC	plu2712	plu4249	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	Peptide chain release factor 3 (RF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	0.707
guaA	rimI	plu2712	plu4250	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	[Ribosomal protein S18]-alanine N-acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18.	0.482
guaA	rplL	plu2712	plu0438	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L7/L12 (L8); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.	0.668
guaA	rplM	plu2712	plu4015	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.815
guaA	rplS	plu2712	plu1260	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	50S ribosomal subunit protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.799
guaA	rplT	plu2712	plu2666	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.428
guaA	rpmA	plu2712	plu4541	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.	0.568
guaA	rpmG	plu2712	plu4863	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family.	0.617
guaA	rpsJ	plu2712	plu4727	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.732
prfA	prfC	plu2070	plu4249	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	Peptide chain release factor 3 (RF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	0.788
prfA	rplL	plu2070	plu0438	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	50S ribosomal protein L7/L12 (L8); Forms part of the ribosomal stalk which helps the ribosome interact with GTP-bound translation factors. Is thus essential for accurate translation; Belongs to the bacterial ribosomal protein bL12 family.	0.535
prfA	rplM	plu2070	plu4015	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	50S ribosomal protein L13; This protein is one of the early assembly proteins of the 50S ribosomal subunit, although it is not seen to bind rRNA by itself. It is important during the early stages of 50S assembly.	0.909
prfA	rplS	plu2070	plu1260	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	50S ribosomal subunit protein L19; This protein is located at the 30S-50S ribosomal subunit interface and may play a role in the structure and function of the aminoacyl-tRNA binding site.	0.885
prfA	rplT	plu2070	plu2666	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	50S ribosomal protein L20; Binds directly to 23S ribosomal RNA and is necessary for the in vitro assembly process of the 50S ribosomal subunit. It is not involved in the protein synthesizing functions of that subunit.	0.911
prfA	rpmA	plu2070	plu4541	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.	0.933
prfA	rpmG	plu2070	plu4863	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	50S ribosomal protein L33; Belongs to the bacterial ribosomal protein bL33 family.	0.726
prfA	rpsJ	plu2070	plu4727	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	30S ribosomal protein S10; Involved in the binding of tRNA to the ribosomes. Belongs to the universal ribosomal protein uS10 family.	0.779
prfC	guaA	plu4249	plu2712	Peptide chain release factor 3 (RF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	GMP synthase [glutamine-hydrolyzing]; Catalyzes the synthesis of GMP from XMP.	0.707
prfC	prfA	plu4249	plu2070	Peptide chain release factor 3 (RF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	Peptide chain release factor 1 (RF-1); Peptide chain release factor 1 directs the termination of translation in response to the peptide chain termination codons UAG and UAA.	0.788
prfC	rimI	plu4249	plu4250	Peptide chain release factor 3 (RF-3); Increases the formation of ribosomal termination complexes and stimulates activities of RF-1 and RF-2. It binds guanine nucleotides and has strong preference for UGA stop codons. It may interact directly with the ribosome. The stimulation of RF-1 and RF-2 is significantly reduced by GTP and GDP, but not by GMP. Belongs to the TRAFAC class translation factor GTPase superfamily. Classic translation factor GTPase family. PrfC subfamily.	[Ribosomal protein S18]-alanine N-acetyltransferase; Acetylates the N-terminal alanine of ribosomal protein S18.	0.736

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