STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
aceAIsocitrate lyase (isocitrase) (isocitratase) (ICL). (435 aa)    
Predicted Functional Partners:
aceB
Malate synthase A (MSA).
 
 0.999
aceK
Isocitrate dehydrogenase kinase/phosphatase (IDH kinase/phosphatase); Bifunctional enzyme which can phosphorylate or dephosphorylate isocitrate dehydrogenase (IDH) on a specific serine residue. This is a regulatory mechanism which enables bacteria to bypass the Krebs cycle via the glyoxylate shunt in response to the source of carbon. When bacteria are grown on glucose, IDH is fully active and unphosphorylated, but when grown on acetate or ethanol, the activity of IDH declines drastically concomitant with its phosphorylation.
 
  
 0.940
acnA
Aconitate hydratase 1 (citrate hydro-lyase 1) (aconitase 1); Catalyzes the isomerization of citrate to isocitrate via cis- aconitate.
   
 
 0.931
acnB
Aconitate hydratase 2 (citrate hydro-lyase 2) (aconitase 2); Belongs to the aconitase/IPM isomerase family.
     
 0.915
ghrA
Glyoxylate/hydroxypyruvate reductase A; Catalyzes the NADPH-dependent reduction of glyoxylate and hydroxypyruvate into glycolate and glycerate, respectively.
   
 
 0.909
eda
KHG/KDPG aldolase [Includes: 4-hydroxy-2-oxoglutarate ldolase (2-keto-4-hydroxyglutarate aldolase) (KHG-aldolase); 2-dehydro-3-deoxyphosphogluconate aldolase (Phospho-2-dehydro-3-deoxygluconate aldolase) (Phospho-2-keto-3-deoxygluconate aldolase) (2-keto-3-deoxy-6-phosphogluconate aldolase) (KDPG-aldolase)].
     
 0.906
plu0950
FAD-binding PCMH-type domain-containing protein; Unnamed protein product; Some similarities with eugenol hydroxylase flavoprotein subunit.
     
 0.904
ackA
Acetate kinase (acetokinase); Catalyzes the formation of acetyl phosphate from acetate and ATP. Can also catalyze the reverse reaction; Belongs to the acetokinase family.
   
  
 0.751
maeB
NADP-dependent malic enzyme (NADP-ME).
   
  
 0.746
pta
Phosphate acetyltransferase (phosphotransacetylase); Involved in acetate metabolism. In the N-terminal section; belongs to the CobB/CobQ family.
   
  
 0.704
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
Server load: low (34%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.