| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ilvA | metA | plu4681 | plu4397 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Homoserine O-succinyltransferase (homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 0.814 |
| ilvA | metB | plu4681 | plu4756 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Cystathionine gamma-synthase (CGS) (O-succinylhomoserine (Thiol)-lyase). | 0.816 |
| ilvA | metL | plu4681 | plu4755 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; homoserine dehydrogenase II]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.703 |
| ilvA | plu0524 | plu4681 | plu0524 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Unnamed protein product; Similar to cystathionine beta-synthase. | 0.924 |
| ilvA | plu3517 | plu4681 | plu3517 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Unnamed protein product; Highly similar to homocysteine synthase. | 0.807 |
| ilvA | sdaA | plu4681 | plu2696 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | L-serine dehydratase 1 (SDH 1); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.922 |
| ilvA | serB | plu4681 | plu0551 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Phosphoserine phosphatase. | 0.904 |
| ilvA | thrA | plu4681 | plu0563 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Aspartokinase I-homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.703 |
| ilvA | trpB | plu4681 | plu2466 | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.929 |
| metA | ilvA | plu4397 | plu4681 | Homoserine O-succinyltransferase (homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.814 |
| metA | metB | plu4397 | plu4756 | Homoserine O-succinyltransferase (homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Cystathionine gamma-synthase (CGS) (O-succinylhomoserine (Thiol)-lyase). | 0.966 |
| metA | metF | plu4397 | plu4754 | Homoserine O-succinyltransferase (homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | 5,10-methylenetetrahydrofolate reductase; Truncated gene. Similar to the N-terminal region of transposase, IS630 family (ISPlu3-p); Belongs to the methylenetetrahydrofolate reductase family. | 0.903 |
| metA | metL | plu4397 | plu4755 | Homoserine O-succinyltransferase (homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; homoserine dehydrogenase II]; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.965 |
| metA | plu0524 | plu4397 | plu0524 | Homoserine O-succinyltransferase (homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Unnamed protein product; Similar to cystathionine beta-synthase. | 0.814 |
| metA | plu3517 | plu4397 | plu3517 | Homoserine O-succinyltransferase (homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Unnamed protein product; Highly similar to homocysteine synthase. | 0.981 |
| metA | sdaA | plu4397 | plu2696 | Homoserine O-succinyltransferase (homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | L-serine dehydratase 1 (SDH 1); Belongs to the iron-sulfur dependent L-serine dehydratase family. | 0.821 |
| metA | serB | plu4397 | plu0551 | Homoserine O-succinyltransferase (homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Phosphoserine phosphatase. | 0.802 |
| metA | thrA | plu4397 | plu0563 | Homoserine O-succinyltransferase (homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Aspartokinase I-homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family. | 0.965 |
| metA | trpB | plu4397 | plu2466 | Homoserine O-succinyltransferase (homoserine O-transsuccinylase) (HTS); Transfers a succinyl group from succinyl-CoA to L-homoserine, forming succinyl-L-homoserine; Belongs to the MetA family. | Tryptophan synthase beta chain; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. | 0.816 |
| metB | ilvA | plu4756 | plu4681 | Cystathionine gamma-synthase (CGS) (O-succinylhomoserine (Thiol)-lyase). | Threonine dehydratase biosynthetic (threonine deaminase); Catalyzes the anaerobic formation of alpha-ketobutyrate and ammonia from threonine in a two-step reaction. The first step involved a dehydration of threonine and a production of enamine intermediates (aminocrotonate), which tautomerizes to its imine form (iminobutyrate). Both intermediates are unstable and short-lived. The second step is the nonenzymatic hydrolysis of the enamine/imine intermediates to form 2- ketobutyrate and free ammonia. In the low water environment of the cell, the second step is accelerated by RidA. | 0.816 |
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