| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| carA | fre | plu0603 | plu4404 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing); Belongs to the CarA family. | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | 0.891 |
| carA | pyrB | plu0603 | plu4492 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing); Belongs to the CarA family. | Aspartate carbamoyltransferase catalytic chain (aspartate transcarbamylase) (ATCase); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.999 |
| carA | pyrE | plu0603 | plu4869 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing); Belongs to the CarA family. | Orotate phosphoribosyltransferase (OPRT) (OPRTASE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.898 |
| carA | pyrF | plu0603 | plu2427 | Carbamoyl-phosphate synthase (glutamine-hydrolyzing); Belongs to the CarA family. | Orotidine-5'-phosphate decarboxylase (OMP decarboxylase); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.899 |
| fre | carA | plu4404 | plu0603 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | Carbamoyl-phosphate synthase (glutamine-hydrolyzing); Belongs to the CarA family. | 0.891 |
| fre | hpaC | plu4404 | plu0974 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | 4-hydroxyphenylacetic acid hydroxylase. | 0.918 |
| fre | plu3812 | plu4404 | plu3812 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | Unnamed protein product; Weakly similar to riboflavin synthase, alpha chain RibE. | 0.901 |
| fre | plu4637 | plu4404 | plu4637 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | Unnamed protein product; Similar to unknown protein YigB of Escherichia coli. | 0.901 |
| fre | pyrB | plu4404 | plu4492 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | Aspartate carbamoyltransferase catalytic chain (aspartate transcarbamylase) (ATCase); Belongs to the aspartate/ornithine carbamoyltransferase superfamily. ATCase family. | 0.902 |
| fre | pyrE | plu4404 | plu4869 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | Orotate phosphoribosyltransferase (OPRT) (OPRTASE); Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP). | 0.905 |
| fre | pyrF | plu4404 | plu2427 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | Orotidine-5'-phosphate decarboxylase (OMP decarboxylase); Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily. | 0.903 |
| fre | ribE | plu4404 | plu2610 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | Riboflavin synthase alpha chain. | 0.901 |
| fre | ribF | plu4404 | plu0590 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | Riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.909 |
| fre | ubiD | plu4404 | plu4405 | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | 3-octaprenyl-4-hydroxybenzoate carboxy-lyase (Polyprenyl p-hydroxybenzoate decarboxylase); Catalyzes the decarboxylation of 3-octaprenyl-4-hydroxy benzoate to 2-octaprenylphenol, an intermediate step in ubiquinone biosynthesis. | 0.917 |
| hpaC | fre | plu0974 | plu4404 | 4-hydroxyphenylacetic acid hydroxylase. | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | 0.918 |
| hpaC | plu3812 | plu0974 | plu3812 | 4-hydroxyphenylacetic acid hydroxylase. | Unnamed protein product; Weakly similar to riboflavin synthase, alpha chain RibE. | 0.902 |
| hpaC | plu4637 | plu0974 | plu4637 | 4-hydroxyphenylacetic acid hydroxylase. | Unnamed protein product; Similar to unknown protein YigB of Escherichia coli. | 0.900 |
| hpaC | ribE | plu0974 | plu2610 | 4-hydroxyphenylacetic acid hydroxylase. | Riboflavin synthase alpha chain. | 0.902 |
| hpaC | ribF | plu0974 | plu0590 | 4-hydroxyphenylacetic acid hydroxylase. | Riboflavin kinase/FMN adenylyltransferase; Belongs to the ribF family. | 0.912 |
| plu3812 | fre | plu3812 | plu4404 | Unnamed protein product; Weakly similar to riboflavin synthase, alpha chain RibE. | NAD(P)H-flavin reductase (NAD(P)H:flavin oxidoreductase). | 0.901 |