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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
metE5-methyltetrahydropteroyltriglutamate--homocysteine methyltransferase; Catalyzes the transfer of a methyl group from 5- methyltetrahydrofolate to homocysteine resulting in methionine formation; Belongs to the vitamin-B12 independent methionine synthase family. (758 aa)    
Predicted Functional Partners:
metK
S-adenosylmethionine synthetase (methionine adenosyltransferase) (AdoMet synthetase) (MAT); Catalyzes the formation of S-adenosylmethionine (AdoMet) from methionine and ATP. The overall synthetic reaction is composed of two sequential steps, AdoMet formation and the subsequent tripolyphosphate hydrolysis which occurs prior to release of AdoMet from the enzyme.
  
 0.976
metC
Cystathionine beta-lyase (CHL) (beta-cystathionase) (cysteine lyase).
  
 
 0.951
plu0523
Unnamed protein product; Similar to cystathionine gamma-lyase.
  
 
 0.947
metB
Cystathionine gamma-synthase (CGS) (O-succinylhomoserine (Thiol)-lyase).
  
 
 0.947
metF
5,10-methylenetetrahydrofolate reductase; Truncated gene. Similar to the N-terminal region of transposase, IS630 family (ISPlu3-p); Belongs to the methylenetetrahydrofolate reductase family.
 
 
 0.944
plu3517
Unnamed protein product; Highly similar to homocysteine synthase.
  
 
 0.935
luxS
Autoinducer-2 (AI-2) production protein LuxS; Involved in the synthesis of autoinducer 2 (AI-2) which is secreted by bacteria and is used to communicate both the cell density and the metabolic potential of the environment. The regulation of gene expression in response to changes in cell density is called quorum sensing. Catalyzes the transformation of S-ribosylhomocysteine (RHC) to homocysteine (HC) and 4,5-dihydroxy-2,3-pentadione (DPD). Belongs to the LuxS family.
    
 0.932
thrA
Aspartokinase I-homoserine dehydrogenase I; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.926
metL
Bifunctional aspartokinase/homoserine dehydrogenase II (AKII-HDII) [Includes: Aspartokinase II; homoserine dehydrogenase II]; In the C-terminal section; belongs to the homoserine dehydrogenase family.
  
 
 0.926
plu0524
Unnamed protein product; Similar to cystathionine beta-synthase.
  
 
 0.924
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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