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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
ispBOctaprenyl-diphosphate synthase (octaprenyl pyrophosphate synthetase) (OPP synthetase); Belongs to the FPP/GGPP synthase family. (323 aa)    
Predicted Functional Partners:
uppS
Undecaprenyl pyrophosphate synthetase; Catalyzes the sequential condensation of isopentenyl diphosphate (IPP) with (2E,6E)-farnesyl diphosphate (E,E-FPP) to yield (2Z,6Z,10Z,14Z,18Z,22Z,26Z,30Z,34E,38E)-undecaprenyl diphosphate (di- trans,octa-cis-UPP). UPP is the precursor of glycosyl carrier lipid in the biosynthesis of bacterial cell wall polysaccharide components such as peptidoglycan and lipopolysaccharide.
 
 
 0.966
ispA
Geranyltranstransferase (farnesyl-diphosphate synthase) FPP synthase); Belongs to the FPP/GGPP synthase family.
  
  
0.923
crtE
CrtE protein; Similar to geranylgeranyl pyrophosphate synthetase (GGPP synthetase); Belongs to the FPP/GGPP synthase family.
  
  
0.923
crtB
Phytoene synthase.
  
 0.908
ubiA
4-hydroxybenzoate octaprenyltransferase (4-HB polyprenyltransferase); Catalyzes the prenylation of para-hydroxybenzoate (PHB) with an all-trans polyprenyl group. Mediates the second step in the final reaction sequence of ubiquinone-8 (UQ-8) biosynthesis, which is the condensation of the polyisoprenoid side chain with PHB, generating the first membrane-bound Q intermediate 3-octaprenyl-4-hydroxybenzoate.
 
 
 0.887
menA
1,4-dihydroxy-2-naphthoate octaprenyltransferase (DHNA-octaprenyltransferase); Conversion of 1,4-dihydroxy-2-naphthoate (DHNA) to demethylmenaquinone (DMK); Belongs to the MenA family. Type 1 subfamily.
    
 0.836
plu4507
APH domain-containing protein; Unnamed protein product; Some similarities with 3-hydroxy-3-methylglutaryl coenzyme A reductase.
 
 
 0.559
plu4506
Unnamed protein product; Hypothetical transmembrane protein.
  
 
 0.552
rpmA
50S ribosomal protein L27; Belongs to the bacterial ribosomal protein bL27 family.
  
    0.542
rplU
50S ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family.
       0.525
Your Current Organism:
Photorhabdus laumondii
NCBI taxonomy Id: 243265
Other names: P. laumondii subsp. laumondii TTO1, Photorhabdus laumondii subsp. laumondii TTO1, Photorhabdus luminescens subsp. laumondii TTO1
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