| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| ACF07104.1 | folD | MARTH_orf180 | MARTH_orf383 | Conserved hypothetical protein. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.748 |
| ACF07104.1 | nusB | MARTH_orf180 | MARTH_orf181 | Conserved hypothetical protein. | Transcription termination factor. | 0.795 |
| ACF07251.1 | folD | MARTH_orf384 | MARTH_orf383 | Conserved hypothetical protein. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.780 |
| ACF07400.1 | cmk | MARTH_orf613 | MARTH_orf302 | 5'-3' exonuclease, exo domain of DNA polymerase I. | Cytidylate kinase. | 0.659 |
| ACF07400.1 | folD | MARTH_orf613 | MARTH_orf383 | 5'-3' exonuclease, exo domain of DNA polymerase I. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.528 |
| ACF07400.1 | glyA | MARTH_orf613 | MARTH_orf743 | 5'-3' exonuclease, exo domain of DNA polymerase I. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.641 |
| ACF07400.1 | nusB | MARTH_orf613 | MARTH_orf181 | 5'-3' exonuclease, exo domain of DNA polymerase I. | Transcription termination factor. | 0.410 |
| ACF07400.1 | secD | MARTH_orf613 | MARTH_orf390 | 5'-3' exonuclease, exo domain of DNA polymerase I. | Protein-export membrane protein SecD. | 0.667 |
| cmk | ACF07400.1 | MARTH_orf302 | MARTH_orf613 | Cytidylate kinase. | 5'-3' exonuclease, exo domain of DNA polymerase I. | 0.659 |
| cmk | folD | MARTH_orf302 | MARTH_orf383 | Cytidylate kinase. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.520 |
| cmk | glyA | MARTH_orf302 | MARTH_orf743 | Cytidylate kinase. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.447 |
| cmk | secD | MARTH_orf302 | MARTH_orf390 | Cytidylate kinase. | Protein-export membrane protein SecD. | 0.572 |
| fmt | folD | MARTH_orf816 | MARTH_orf383 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.588 |
| fmt | nusB | MARTH_orf816 | MARTH_orf181 | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | Transcription termination factor. | 0.861 |
| folD | ACF07104.1 | MARTH_orf383 | MARTH_orf180 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Conserved hypothetical protein. | 0.748 |
| folD | ACF07251.1 | MARTH_orf383 | MARTH_orf384 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Conserved hypothetical protein. | 0.780 |
| folD | ACF07400.1 | MARTH_orf383 | MARTH_orf613 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5'-3' exonuclease, exo domain of DNA polymerase I. | 0.528 |
| folD | cmk | MARTH_orf383 | MARTH_orf302 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Cytidylate kinase. | 0.520 |
| folD | fmt | MARTH_orf383 | MARTH_orf816 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | methionyl-tRNA formyltransferase; Attaches a formyl group to the free amino group of methionyl- tRNA(fMet). The formyl group appears to play a dual role in the initiator identity of N-formylmethionyl-tRNA by promoting its recognition by IF2 and preventing the misappropriation of this tRNA by the elongation apparatus; Belongs to the Fmt family. | 0.588 |
| folD | glyA | MARTH_orf383 | MARTH_orf743 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.964 |
