STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
polCDNA polymerase III subunit alpha; Required for replicative DNA synthesis. This DNA polymerase also exhibits 3' to 5' exonuclease activity. (1438 aa)    
Predicted Functional Partners:
dnaE
DNA polymerase III subunit alpha.
 
  
0.950
dnaX
DNA polymerase III subunits gamma and tau; DNA polymerase III is a complex, multichain enzyme responsible for most of the replicative synthesis in bacteria. This DNA polymerase also exhibits 3' to 5' exonuclease activity.
  
 0.947
dnaN
DNA polymerase III, beta subunit.
   
 0.946
holA
DNA polymerase III, delta subunit.
    
 0.926
holB
DNA polymerase III subunit delta.
  
 0.918
ACF07400.1
5'-3' exonuclease, exo domain of DNA polymerase I.
   
 
 0.845
cdsA
Phosphatidate cytidylyltransferase; Belongs to the CDS family.
       0.769
pgiB
Glucose-6-phosphate isomerase.
 
  
 0.695
whiA
Conserved hypothetical protein; Involved in cell division and chromosome segregation.
 
     0.637
topA
DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...]
  
  
 0.583
Your Current Organism:
Mycoplasma arthritidis
NCBI taxonomy Id: 243272
Other names: M. arthritidis 158L3-1, Mycoplasma arthritidis 158L3-1, Mycoplasma arthritidis str. 158L3-1, Mycoplasma arthritidis strain 158L3-1
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.