node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MG_010 | MG_220 | MG_010 | MG_220 | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | Conserved hypothetical protein; MG220 has 1 transmembrane region; identified by similarity to EGAD:57057. | 0.750 |
MG_010 | MG_390 | MG_010 | MG_390 | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | ABC transporter, ATP-binding/permease protein; MG390 has 4 transmembrane regions, plus and ATP binding domain, and a peptidase domain. There is no predicted substrate binding protein or other ABC transporter component in the vicinity; identified by similarity to GB:AAA03343.1; match to protein family HMM PF00005; match to protein family HMM PF03412. | 0.700 |
MG_010 | MG_414 | MG_010 | MG_414 | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | Conserved hypothetical protein; Gene disruption mutants in MG414 have 16% faster doubling times than wild type M. genitalium (Glass et al. 2005). MG414 has 1 transmembrane region; identified by similarity to EGAD:56835. | 0.745 |
MG_010 | MG_525 | MG_010 | MG_525 | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | Conserved hypothetical protein. | 0.750 |
MG_010 | dnaB | MG_010 | MG_094 | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | Replicative DNA helicase; Participates in initiation and elongation during chromosome replication; it exhibits DNA-dependent ATPase activity. | 0.893 |
MG_010 | dnaG | MG_010 | MG_250 | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | DNA primase; RNA polymerase that catalyzes the synthesis of short RNA molecules used as primers for DNA polymerase during DNA replication. | 0.907 |
MG_010 | gyrA | MG_010 | MG_004 | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | DNA gyrase, A subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.692 |
MG_010 | gyrB | MG_010 | MG_003 | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | DNA gyrase, B subunit; A type II topoisomerase that negatively supercoils closed circular double-stranded (ds) DNA in an ATP-dependent manner to modulate DNA topology and maintain chromosomes in an underwound state. Negative supercoiling favors strand separation, and DNA replication, transcription, recombination and repair, all of which involve strand separation. Also able to catalyze the interconversion of other topological isomers of dsDNA rings, including catenanes and knotted rings. Type II topoisomerases break and join 2 DNA strands simultaneously in an ATP-dependent manner. | 0.718 |
MG_010 | tmk | MG_010 | MG_006 | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.712 |
MG_010 | topA | MG_010 | MG_122 | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | DNA topoisomerase I; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA supe [...] | 0.689 |
MG_220 | MG_010 | MG_220 | MG_010 | Conserved hypothetical protein; MG220 has 1 transmembrane region; identified by similarity to EGAD:57057. | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | 0.750 |
MG_220 | MG_390 | MG_220 | MG_390 | Conserved hypothetical protein; MG220 has 1 transmembrane region; identified by similarity to EGAD:57057. | ABC transporter, ATP-binding/permease protein; MG390 has 4 transmembrane regions, plus and ATP binding domain, and a peptidase domain. There is no predicted substrate binding protein or other ABC transporter component in the vicinity; identified by similarity to GB:AAA03343.1; match to protein family HMM PF00005; match to protein family HMM PF03412. | 0.644 |
MG_220 | MG_414 | MG_220 | MG_414 | Conserved hypothetical protein; MG220 has 1 transmembrane region; identified by similarity to EGAD:57057. | Conserved hypothetical protein; Gene disruption mutants in MG414 have 16% faster doubling times than wild type M. genitalium (Glass et al. 2005). MG414 has 1 transmembrane region; identified by similarity to EGAD:56835. | 0.695 |
MG_220 | MG_525 | MG_220 | MG_525 | Conserved hypothetical protein; MG220 has 1 transmembrane region; identified by similarity to EGAD:57057. | Conserved hypothetical protein. | 0.750 |
MG_390 | MG_010 | MG_390 | MG_010 | ABC transporter, ATP-binding/permease protein; MG390 has 4 transmembrane regions, plus and ATP binding domain, and a peptidase domain. There is no predicted substrate binding protein or other ABC transporter component in the vicinity; identified by similarity to GB:AAA03343.1; match to protein family HMM PF00005; match to protein family HMM PF03412. | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | 0.700 |
MG_390 | MG_220 | MG_390 | MG_220 | ABC transporter, ATP-binding/permease protein; MG390 has 4 transmembrane regions, plus and ATP binding domain, and a peptidase domain. There is no predicted substrate binding protein or other ABC transporter component in the vicinity; identified by similarity to GB:AAA03343.1; match to protein family HMM PF00005; match to protein family HMM PF03412. | Conserved hypothetical protein; MG220 has 1 transmembrane region; identified by similarity to EGAD:57057. | 0.644 |
MG_390 | MG_414 | MG_390 | MG_414 | ABC transporter, ATP-binding/permease protein; MG390 has 4 transmembrane regions, plus and ATP binding domain, and a peptidase domain. There is no predicted substrate binding protein or other ABC transporter component in the vicinity; identified by similarity to GB:AAA03343.1; match to protein family HMM PF00005; match to protein family HMM PF03412. | Conserved hypothetical protein; Gene disruption mutants in MG414 have 16% faster doubling times than wild type M. genitalium (Glass et al. 2005). MG414 has 1 transmembrane region; identified by similarity to EGAD:56835. | 0.750 |
MG_390 | MG_525 | MG_390 | MG_525 | ABC transporter, ATP-binding/permease protein; MG390 has 4 transmembrane regions, plus and ATP binding domain, and a peptidase domain. There is no predicted substrate binding protein or other ABC transporter component in the vicinity; identified by similarity to GB:AAA03343.1; match to protein family HMM PF00005; match to protein family HMM PF03412. | Conserved hypothetical protein. | 0.642 |
MG_414 | MG_010 | MG_414 | MG_010 | Conserved hypothetical protein; Gene disruption mutants in MG414 have 16% faster doubling times than wild type M. genitalium (Glass et al. 2005). MG414 has 1 transmembrane region; identified by similarity to EGAD:56835. | DNA primase-related protein; Identified by similarity to EGAD:56796; match to protein family HMM PF01751; match to protein family HMM TIGR00646. | 0.745 |
MG_414 | MG_220 | MG_414 | MG_220 | Conserved hypothetical protein; Gene disruption mutants in MG414 have 16% faster doubling times than wild type M. genitalium (Glass et al. 2005). MG414 has 1 transmembrane region; identified by similarity to EGAD:56835. | Conserved hypothetical protein; MG220 has 1 transmembrane region; identified by similarity to EGAD:57057. | 0.695 |