node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MG_233 | MG_236 | MG_233 | MG_236 | Conserved hypothetical protein; Identified by similarity to EGAD:56995; match to protein family HMM PF04327. | Expressed protein of unknown function; MG236 is similar to transcriptional regulators of the Fur family. The expression of this M. genitalium protein was reported in a proteome analysis (Eur. J. Biochem. 267, 1571-1582 (2000)); identified by similarity to EGAD:56975. | 0.917 |
MG_233 | MG_237 | MG_233 | MG_237 | Conserved hypothetical protein; Identified by similarity to EGAD:56995; match to protein family HMM PF04327. | Conserved hypothetical protein; Identified by similarity to EGAD:56970. | 0.940 |
MG_233 | dhfR | MG_233 | MG_228 | Conserved hypothetical protein; Identified by similarity to EGAD:56995; match to protein family HMM PF04327. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.502 |
MG_233 | nrdE | MG_233 | MG_231 | Conserved hypothetical protein; Identified by similarity to EGAD:56995; match to protein family HMM PF04327. | Ribonucleoside-diphosphate reductase, alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.537 |
MG_233 | nrdF | MG_233 | MG_229 | Conserved hypothetical protein; Identified by similarity to EGAD:56995; match to protein family HMM PF04327. | Ribonucleoside-diphosphate reductase, beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.502 |
MG_233 | nrdI | MG_233 | MG_230 | Conserved hypothetical protein; Identified by similarity to EGAD:56995; match to protein family HMM PF04327. | nrdI protein; Probably involved in ribonucleotide reductase function. | 0.502 |
MG_233 | rplU | MG_233 | MG_232 | Conserved hypothetical protein; Identified by similarity to EGAD:56995; match to protein family HMM PF04327. | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.973 |
MG_233 | rpmA | MG_233 | MG_234 | Conserved hypothetical protein; Identified by similarity to EGAD:56995; match to protein family HMM PF04327. | Ribosomal protein L27; Identified by similarity to SP:P05657; match to protein family HMM PF01016; match to protein family HMM TIGR00062; Belongs to the bacterial ribosomal protein bL27 family. | 0.990 |
MG_233 | thyA | MG_233 | MG_227 | Conserved hypothetical protein; Identified by similarity to EGAD:56995; match to protein family HMM PF04327. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.515 |
MG_236 | MG_233 | MG_236 | MG_233 | Expressed protein of unknown function; MG236 is similar to transcriptional regulators of the Fur family. The expression of this M. genitalium protein was reported in a proteome analysis (Eur. J. Biochem. 267, 1571-1582 (2000)); identified by similarity to EGAD:56975. | Conserved hypothetical protein; Identified by similarity to EGAD:56995; match to protein family HMM PF04327. | 0.917 |
MG_236 | MG_237 | MG_236 | MG_237 | Expressed protein of unknown function; MG236 is similar to transcriptional regulators of the Fur family. The expression of this M. genitalium protein was reported in a proteome analysis (Eur. J. Biochem. 267, 1571-1582 (2000)); identified by similarity to EGAD:56975. | Conserved hypothetical protein; Identified by similarity to EGAD:56970. | 0.908 |
MG_236 | dhfR | MG_236 | MG_228 | Expressed protein of unknown function; MG236 is similar to transcriptional regulators of the Fur family. The expression of this M. genitalium protein was reported in a proteome analysis (Eur. J. Biochem. 267, 1571-1582 (2000)); identified by similarity to EGAD:56975. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.507 |
MG_236 | nrdE | MG_236 | MG_231 | Expressed protein of unknown function; MG236 is similar to transcriptional regulators of the Fur family. The expression of this M. genitalium protein was reported in a proteome analysis (Eur. J. Biochem. 267, 1571-1582 (2000)); identified by similarity to EGAD:56975. | Ribonucleoside-diphosphate reductase, alpha chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.548 |
MG_236 | nrdF | MG_236 | MG_229 | Expressed protein of unknown function; MG236 is similar to transcriptional regulators of the Fur family. The expression of this M. genitalium protein was reported in a proteome analysis (Eur. J. Biochem. 267, 1571-1582 (2000)); identified by similarity to EGAD:56975. | Ribonucleoside-diphosphate reductase, beta chain; Provides the precursors necessary for DNA synthesis. Catalyzes the biosynthesis of deoxyribonucleotides from the corresponding ribonucleotides (By similarity). | 0.512 |
MG_236 | nrdI | MG_236 | MG_230 | Expressed protein of unknown function; MG236 is similar to transcriptional regulators of the Fur family. The expression of this M. genitalium protein was reported in a proteome analysis (Eur. J. Biochem. 267, 1571-1582 (2000)); identified by similarity to EGAD:56975. | nrdI protein; Probably involved in ribonucleotide reductase function. | 0.521 |
MG_236 | rplU | MG_236 | MG_232 | Expressed protein of unknown function; MG236 is similar to transcriptional regulators of the Fur family. The expression of this M. genitalium protein was reported in a proteome analysis (Eur. J. Biochem. 267, 1571-1582 (2000)); identified by similarity to EGAD:56975. | Ribosomal protein L21; This protein binds to 23S rRNA in the presence of protein L20; Belongs to the bacterial ribosomal protein bL21 family. | 0.856 |
MG_236 | rpmA | MG_236 | MG_234 | Expressed protein of unknown function; MG236 is similar to transcriptional regulators of the Fur family. The expression of this M. genitalium protein was reported in a proteome analysis (Eur. J. Biochem. 267, 1571-1582 (2000)); identified by similarity to EGAD:56975. | Ribosomal protein L27; Identified by similarity to SP:P05657; match to protein family HMM PF01016; match to protein family HMM TIGR00062; Belongs to the bacterial ribosomal protein bL27 family. | 0.862 |
MG_236 | thyA | MG_236 | MG_227 | Expressed protein of unknown function; MG236 is similar to transcriptional regulators of the Fur family. The expression of this M. genitalium protein was reported in a proteome analysis (Eur. J. Biochem. 267, 1571-1582 (2000)); identified by similarity to EGAD:56975. | Thymidylate synthase; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor and reductant in the reaction, yielding dihydrofolate (DHF) as a by- product. This enzymatic reaction provides an intracellular de novo source of dTMP, an essential precursor for DNA biosynthesis. | 0.502 |
MG_237 | MG_233 | MG_237 | MG_233 | Conserved hypothetical protein; Identified by similarity to EGAD:56970. | Conserved hypothetical protein; Identified by similarity to EGAD:56995; match to protein family HMM PF04327. | 0.940 |
MG_237 | MG_236 | MG_237 | MG_236 | Conserved hypothetical protein; Identified by similarity to EGAD:56970. | Expressed protein of unknown function; MG236 is similar to transcriptional regulators of the Fur family. The expression of this M. genitalium protein was reported in a proteome analysis (Eur. J. Biochem. 267, 1571-1582 (2000)); identified by similarity to EGAD:56975. | 0.908 |