node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
MG_245 | MG_322 | MG_245 | MG_322 | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | Potassium uptake protein, TrkH family, putative; The adjacent gene, MG323, is a likely TrkA accessory protein for this gene which has some similarity to TrkH potassium transporters. MG322 has 9 transmembrane regions; identified by similarity to EGAD:57154; match to protein family HMM PF02386. | 0.764 |
MG_245 | MG_323 | MG_245 | MG_323 | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | Potassium uptake protein, TrkA family; MG322, the adjacent gene, which is on the opposite strand encodes a trk potassium uptake protein. MG323 is a likely accessory protein; identified by similarity to EGAD:57150; match to protein family HMM PF02080; match to protein family HMM PF02254. | 0.803 |
MG_245 | lon | MG_245 | MG_239 | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.717 |
MG_245 | pacL | MG_245 | MG_071 | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | ATPase, P-type (transporting), HAD superfamily, subfamily IC; Could mediate calcium influx. | 0.750 |
MG_245 | pepA | MG_245 | MG_391 | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity). | 0.682 |
MG_245 | pepF | MG_245 | MG_183 | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | Identified by similarity to SP:Q53778; match to protein family HMM PF01432; match to protein family HMM TIGR00181. | 0.669 |
MG_322 | MG_245 | MG_322 | MG_245 | Potassium uptake protein, TrkH family, putative; The adjacent gene, MG323, is a likely TrkA accessory protein for this gene which has some similarity to TrkH potassium transporters. MG322 has 9 transmembrane regions; identified by similarity to EGAD:57154; match to protein family HMM PF02386. | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | 0.764 |
MG_322 | MG_323 | MG_322 | MG_323 | Potassium uptake protein, TrkH family, putative; The adjacent gene, MG323, is a likely TrkA accessory protein for this gene which has some similarity to TrkH potassium transporters. MG322 has 9 transmembrane regions; identified by similarity to EGAD:57154; match to protein family HMM PF02386. | Potassium uptake protein, TrkA family; MG322, the adjacent gene, which is on the opposite strand encodes a trk potassium uptake protein. MG323 is a likely accessory protein; identified by similarity to EGAD:57150; match to protein family HMM PF02080; match to protein family HMM PF02254. | 0.999 |
MG_322 | lon | MG_322 | MG_239 | Potassium uptake protein, TrkH family, putative; The adjacent gene, MG323, is a likely TrkA accessory protein for this gene which has some similarity to TrkH potassium transporters. MG322 has 9 transmembrane regions; identified by similarity to EGAD:57154; match to protein family HMM PF02386. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.654 |
MG_322 | pacL | MG_322 | MG_071 | Potassium uptake protein, TrkH family, putative; The adjacent gene, MG323, is a likely TrkA accessory protein for this gene which has some similarity to TrkH potassium transporters. MG322 has 9 transmembrane regions; identified by similarity to EGAD:57154; match to protein family HMM PF02386. | ATPase, P-type (transporting), HAD superfamily, subfamily IC; Could mediate calcium influx. | 0.775 |
MG_322 | pepA | MG_322 | MG_391 | Potassium uptake protein, TrkH family, putative; The adjacent gene, MG323, is a likely TrkA accessory protein for this gene which has some similarity to TrkH potassium transporters. MG322 has 9 transmembrane regions; identified by similarity to EGAD:57154; match to protein family HMM PF02386. | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity). | 0.688 |
MG_322 | pepF | MG_322 | MG_183 | Potassium uptake protein, TrkH family, putative; The adjacent gene, MG323, is a likely TrkA accessory protein for this gene which has some similarity to TrkH potassium transporters. MG322 has 9 transmembrane regions; identified by similarity to EGAD:57154; match to protein family HMM PF02386. | Identified by similarity to SP:Q53778; match to protein family HMM PF01432; match to protein family HMM TIGR00181. | 0.669 |
MG_323 | MG_245 | MG_323 | MG_245 | Potassium uptake protein, TrkA family; MG322, the adjacent gene, which is on the opposite strand encodes a trk potassium uptake protein. MG323 is a likely accessory protein; identified by similarity to EGAD:57150; match to protein family HMM PF02080; match to protein family HMM PF02254. | 5-formyltetrahydrofolate cyclo-ligase, putative; Involved in folate metabolism. Catalyzes the irreversible conversion of 5-formyltetrahydrofolate (5-FTHF) to yield 5,10- methenyltetrahydrofolate (By similarity). | 0.803 |
MG_323 | MG_322 | MG_323 | MG_322 | Potassium uptake protein, TrkA family; MG322, the adjacent gene, which is on the opposite strand encodes a trk potassium uptake protein. MG323 is a likely accessory protein; identified by similarity to EGAD:57150; match to protein family HMM PF02080; match to protein family HMM PF02254. | Potassium uptake protein, TrkH family, putative; The adjacent gene, MG323, is a likely TrkA accessory protein for this gene which has some similarity to TrkH potassium transporters. MG322 has 9 transmembrane regions; identified by similarity to EGAD:57154; match to protein family HMM PF02386. | 0.999 |
MG_323 | lon | MG_323 | MG_239 | Potassium uptake protein, TrkA family; MG322, the adjacent gene, which is on the opposite strand encodes a trk potassium uptake protein. MG323 is a likely accessory protein; identified by similarity to EGAD:57150; match to protein family HMM PF02080; match to protein family HMM PF02254. | ATP-dependent protease La; ATP-dependent serine protease that mediates the selective degradation of mutant and abnormal proteins as well as certain short- lived regulatory proteins. Required for cellular homeostasis and for survival from DNA damage and developmental changes induced by stress. Degrades polypeptides processively to yield small peptide fragments that are 5 to 10 amino acids long. Binds to DNA in a double-stranded, site-specific manner. | 0.659 |
MG_323 | pacL | MG_323 | MG_071 | Potassium uptake protein, TrkA family; MG322, the adjacent gene, which is on the opposite strand encodes a trk potassium uptake protein. MG323 is a likely accessory protein; identified by similarity to EGAD:57150; match to protein family HMM PF02080; match to protein family HMM PF02254. | ATPase, P-type (transporting), HAD superfamily, subfamily IC; Could mediate calcium influx. | 0.832 |
MG_323 | pepA | MG_323 | MG_391 | Potassium uptake protein, TrkA family; MG322, the adjacent gene, which is on the opposite strand encodes a trk potassium uptake protein. MG323 is a likely accessory protein; identified by similarity to EGAD:57150; match to protein family HMM PF02080; match to protein family HMM PF02254. | Cytosol aminopeptidase; Presumably involved in the processing and regular turnover of intracellular proteins. Catalyzes the removal of unsubstituted N- terminal amino acids from various peptides (By similarity). | 0.682 |
MG_323 | pepF | MG_323 | MG_183 | Potassium uptake protein, TrkA family; MG322, the adjacent gene, which is on the opposite strand encodes a trk potassium uptake protein. MG323 is a likely accessory protein; identified by similarity to EGAD:57150; match to protein family HMM PF02080; match to protein family HMM PF02254. | Identified by similarity to SP:Q53778; match to protein family HMM PF01432; match to protein family HMM TIGR00181. | 0.667 |
clpB | ftsH | MG_355 | MG_457 | ATP-dependent Clp protease, ATPase subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ [...] | ATP-dependent metalloprotease FtsH; Acts as a processive, ATP-dependent zinc metallopeptidase for both cytoplasmic and membrane proteins. Plays a role in the quality control of integral membrane proteins; In the central section; belongs to the AAA ATPase family. | 0.506 |
clpB | grpE | MG_355 | MG_201 | ATP-dependent Clp protease, ATPase subunit; Part of a stress-induced multi-chaperone system, it is involved in the recovery of the cell from heat-induced damage, in cooperation with DnaK, DnaJ and GrpE. Acts before DnaK, in the processing of protein aggregates. Protein binding stimulates the ATPase activity; ATP hydrolysis unfolds the denatured protein aggregates, which probably helps expose new hydrophobic binding sites on the surface of ClpB-bound aggregates, contributing to the solubilization and refolding of denatured protein aggregates by DnaK (By similarity). Belongs to the ClpA/ [...] | Co-chaperone GrpE; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-depend [...] | 0.841 |