STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM_0161Geranyltranstransferase; Similar to GB:D13293 SP:Q08291 GB:S72629 GB:S72630 GB:S72633 percent identity: 62.08; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family. (272 aa)    
Predicted Functional Partners:
uppS
Conserved hypothetical protein; Catalyzes the condensation of isopentenyl diphosphate (IPP) with allylic pyrophosphates generating different type of terpenoids.
 
 
 0.997
TM_1535
Octoprenyl-diphosphate synthase, putative; Similar to GB:AE000657 percent identity: 62.05; identified by sequence similarity; putative; Belongs to the FPP/GGPP synthase family.
  
  
 
0.993
ispH
lytB protein; Catalyzes the conversion of 1-hydroxy-2-methyl-2-(E)-butenyl 4-diphosphate (HMBPP) into a mixture of isopentenyl diphosphate (IPP) and dimethylallyl diphosphate (DMAPP). Acts in the terminal step of the DOXP/MEP pathway for isoprenoid precursor biosynthesis. Belongs to the IspH family.
 
 
 0.992
TM_1555
Hypothetical protein; Identified by sequence similarity; putative.
  
 
 0.992
TM_0160
Conserved hypothetical protein; Similar to GB:AE000657 percent identity: 68.55; identified by sequence similarity; putative.
       0.827
TM_0162
Hypothetical protein; Identified by sequence similarity; putative.
       0.826
TM_0163
Hypothetical protein; Identified by sequence similarity; putative.
  
    0.811
TM_0164
Conserved hypothetical protein; Similar to GB:AE000666 percent identity: 61.11; identified by sequence similarity; putative.
       0.783
dxs
1-deoxyxylulose-5-phosphate synthase; Catalyzes the acyloin condensation reaction between C atoms 2 and 3 of pyruvate and glyceraldehyde 3-phosphate to yield 1-deoxy-D- xylulose-5-phosphate (DXP); Belongs to the transketolase family. DXPS subfamily.
  
 0.772
TM_0159
Ham1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
    0.732
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
Server load: low (36%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.