STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM_0177Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 58.97; identified by sequence similarity; putative. (283 aa)    
Predicted Functional Partners:
TM_0159
Ham1 protein; Pyrophosphatase that catalyzes the hydrolysis of nucleoside triphosphates to their monophosphate derivatives, with a high preference for the non-canonical purine nucleotides XTP (xanthosine triphosphate), dITP (deoxyinosine triphosphate) and ITP. Seems to function as a house-cleaning enzyme that removes non-canonical purine nucleotides from the nucleotide pool, thus preventing their incorporation into DNA/RNA and avoiding chromosomal lesions. Belongs to the HAM1 NTPase family.
 
    0.893
priA
Primosomal protein N; Involved in the restart of stalled replication forks. Recognizes and binds the arrested nascent DNA chain at stalled replication forks. It can open the DNA duplex, via its helicase activity, and promote assembly of the primosome and loading of the major replicative helicase DnaB onto DNA; Belongs to the helicase family. PriA subfamily.
       0.810
acpP
Acyl carrier protein; Carrier of the growing fatty acid chain in fatty acid biosynthesis; Belongs to the acyl carrier protein (ACP) family.
       0.742
TM_0176
Conserved hypothetical protein; Similar to GB:AE000657 percent identity: 58.27; identified by sequence similarity; putative.
       0.742
TM_0171
Conserved hypothetical protein; Similar to SP:P54452 PID:1303787 GB:AL009126 percent identity: 52.08; identified by sequence similarity; putative.
 
     0.683
leuS
leucyl-tRNA synthetase; Similar to PID:1652380 percent identity: 69.10; identified by sequence similarity; putative; Belongs to the class-I aminoacyl-tRNA synthetase family.
  
    0.580
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
  0.564
rex1
Conserved hypothetical protein; Modulates transcription in response to changes in cellular NADH/NAD(+) redox state.
       0.562
TM_0170
Hypothetical protein; Identified by sequence similarity; putative.
       0.562
ahcY
Adenosylhomocysteinase; May play a key role in the regulation of the intracellular concentration of adenosylhomocysteine.
       0.562
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.