STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
TM_0186Response regulator; Phosphodiesterase (PDE) that catalyzes the hydrolysis of cyclic diguanylate (c-di-GMP) to GMP. Hydrolyzes c-di-GMP to GMP in a two-step reaction, via the linear intermediate 5'- phosphoguanylyl(3'->5')guanosine (pGpG). (368 aa)    
Predicted Functional Partners:
TM_0972
Conserved hypothetical protein, GGDEF domain; Similar to GB:AE000657 percent identity: 63.80; identified by sequence similarity; putative.
 
  
 0.908
TM_1788
Conserved hypothetical protein, GGDEF domain; Similar to GB:AE000657 percent identity: 60.13; identified by sequence similarity; putative.
 
  
 0.859
TM_1184
pleD-related protein; Similar to PID:1652841 percent identity: 50.78; identified by sequence similarity; putative.
 0.775
TM_0185
Hypothetical protein; Identified by sequence similarity; putative.
       0.685
TM_0143
Response regulator; Similar to PID:1651878 percent identity: 53.02; identified by sequence similarity; putative.
 
 0.678
TM_0853
Sensor histidine kinase; Similar to PID:1575578 GB:AE000512 percent identity: 61.11; identified by sequence similarity; putative.
 0.614
TM_1588
Conserved hypothetical protein, GGDEF domain; Similar to GB:AE000657 percent identity: 57.07; identified by sequence similarity; putative.
 
  
 0.591
ribBA
GTP cyclohydrolase II/3,4-dihydroxy-2-butanone 4-phosphate synthase; Catalyzes the conversion of D-ribulose 5-phosphate to formate and 3,4-dihydroxy-2-butanone 4-phosphate; In the N-terminal section; belongs to the DHBP synthase family.
     
  0.591
TM_0221
Flagellar M-ring protein; The M ring may be actively involved in energy transduction. Belongs to the FliF family.
   
    0.569
TM_0400
Sensor histidine kinase; Similar to PID:1001613 PID:1001628 percent identity: 54.23; identified by sequence similarity; putative.
 
 0.551
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
Server load: low (16%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.