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STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM_0250DNA processing chain A; Similar to GB:L42023 SP:P43862 PID:1006171 PID:1221098 PID:609332 percent identity: 61.21; identified by sequence similarity; putative. (337 aa)    
Predicted Functional Partners:
TM_0513
comM protein; Similar to GB:L42023 SP:P45049 PID:1006428 PID:1221236 PID:1205364 percent identity: 64.26; identified by sequence similarity; putative.
 
 0.938
topA
DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superc [...]
   
 0.867
TM_0249
rnfB-related protein; Similar to GB:D13625 PID:216928 PID:435526 PID:1905809 percent identity: 64.86; identified by sequence similarity; putative.
       0.827
TM_0253
Conserved hypothetical protein; Similar to GB:AE000511 PID:2313953 percent identity: 58.00; identified by sequence similarity; putative; Belongs to the UPF0102 family.
  
    0.825
TM_0243
Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 58.74; identified by sequence similarity; putative.
       0.824
rnfC
Electron transport complex protein, putative; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the 4Fe4S bacterial-type ferredoxin family. RnfC subfamily.
       0.824
rnfG
Hypothetical protein; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the RnfG family.
       0.824
rnfE
Na-translocating NADH-quinone reductase, Nqr4 subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
       0.824
rnfA
Na-translocating NADH-quinone reductase, Nqr5 subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
       0.824
rnfD
Na-translocating NADH-quinone reductase, Nqr2 subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane. Belongs to the NqrB/RnfD family.
       0.811
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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