STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
estDConserved hypothetical protein; Exhibits significant esterase activity with a preference for short acyl chain esters (C4-C8) in vitro. Its physiological function is not known. Displays neither proteolytic activity using casein as substrate, nor peptidase activity when assayed with L-leucine p- nitroanilide and L-proline p-nitroanilide. Belongs to the AB hydrolase superfamily. Esterase 10 family. (412 aa)    
Predicted Functional Partners:
TM_0337
Conserved hypothetical protein; Similar to GB:L77117 PID:1591784 percent identity: 67.50; identified by sequence similarity; putative.
 
     0.839
pyrF
Orotidine 5'-phosphate decarboxylase, putative; Catalyzes the decarboxylation of orotidine 5'-monophosphate (OMP) to uridine 5'-monophosphate (UMP); Belongs to the OMP decarboxylase family. Type 1 subfamily.
    
  0.786
TM_0330
Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 55.17; identified by sequence similarity; putative.
 
     0.743
pyrD
Dihydroorotate dehydrogenase; Catalyzes the conversion of dihydroorotate to orotate with NAD(+) as electron acceptor; Belongs to the dihydroorotate dehydrogenase family. Type 1 subfamily.
  
    0.716
TM_0329
Hypothetical protein; Identified by sequence similarity; putative.
       0.709
pyrE
Orotate phosphoribosyltransferase; Catalyzes the transfer of a ribosyl phosphate group from 5- phosphoribose 1-diphosphate to orotate, leading to the formation of orotidine monophosphate (OMP).
       0.709
pyrC
Dihydroorotase; Catalyzes the reversible cyclization of carbamoyl aspartate to dihydroorotate; Belongs to the metallo-dependent hydrolases superfamily. DHOase family. Class I DHOase subfamily.
       0.709
TM_0751
Uridine kinase-related protein; Similar to GB:U00089 SP:P75217 PID:1673952 percent identity: 52.11; identified by sequence similarity; putative.
    
  0.702
pyrK
Dihydroorotate dehydrogenase electron transfer protein; Responsible for channeling the electrons from the oxidation of dihydroorotate from the FMN redox center in the PyrD type B subunit to the ultimate electron acceptor NAD(+).
       0.693
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
    
  0.686
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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