STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
nthEndonuclease III; DNA repair enzyme that has both DNA N-glycosylase activity and AP-lyase activity. The DNA N-glycosylase activity releases various damaged pyrimidines from DNA by cleaving the N-glycosidic bond, leaving an AP (apurinic/apyrimidinic) site. The AP-lyase activity cleaves the phosphodiester bond 3' to the AP site by a beta-elimination, leaving a 3'-terminal unsaturated sugar and a product with a terminal 5'- phosphate. (213 aa)    
Predicted Functional Partners:
nfo
Deoxyribonuclease IV; Endonuclease IV plays a role in DNA repair. It cleaves phosphodiester bonds at apurinic or apyrimidinic (AP) sites, generating a 3'-hydroxyl group and a 5'-terminal sugar phosphate.
  
 
 0.972
TM_0367
Conserved hypothetical protein; Similar to GB:AE000782 percent identity: 70.18; identified by sequence similarity; putative.
       0.813
apeA
Aminopeptidase, putative; Similar to GB:X78708 PID:472885 GB:AE000783 percent identity: 69.09; identified by sequence similarity; putative.
     
 0.810
TM_0363
Fibronectin-binding protein, putative; Similar to GB:AL009126 percent identity: 53.99; identified by sequence similarity; putative.
       0.804
mgtA
4-alpha-glucanotransferase; Similar to GP:951311 percent identity: 99.77; identified by sequence similarity; putative; Belongs to the glycosyl hydrolase 13 family.
  
    0.804
rnfE
Na-translocating NADH-quinone reductase, Nqr4 subunit; Part of a membrane-bound complex that couples electron transfer with translocation of ions across the membrane.
 
  
 0.796
polA
DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
   
 
 0.782
TM_0005
DNA helicase, putative; Similar to GB:AE000782 percent identity: 77.56; identified by sequence similarity; putative.
 
     0.746
TM_0966
Conserved hypothetical protein; Similar to PID:1652988 percent identity: 67.30; identified by sequence similarity; putative.
 
    0.733
TM_0990
Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 71.88; identified by sequence similarity; putative.
  
 
 0.636
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.