| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TM_0198 | TM_0374 | TM_0198 | TM_0374 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Heat shock protein, class I; Similar to GB:AE000657 percent identity: 70.37; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | 0.817 |
| TM_0198 | dnaJ | TM_0198 | TM_0849 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.783 |
| TM_0198 | dnaK | TM_0198 | TM_0373 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.960 |
| TM_0198 | groL | TM_0198 | TM_0506 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | groEL protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.633 |
| TM_0198 | groS | TM_0198 | TM_0505 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | groES protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.645 |
| TM_0198 | grpE | TM_0198 | TM_0850 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | grpE protein, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | 0.798 |
| TM_0198 | hrcA | TM_0198 | TM_0851 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Heat shock operon repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.539 |
| TM_0374 | TM_0198 | TM_0374 | TM_0198 | Heat shock protein, class I; Similar to GB:AE000657 percent identity: 70.37; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | 0.817 |
| TM_0374 | TM_1391 | TM_0374 | TM_1391 | Heat shock protein, class I; Similar to GB:AE000657 percent identity: 70.37; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 73.97; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | 0.819 |
| TM_0374 | dnaJ | TM_0374 | TM_0849 | Heat shock protein, class I; Similar to GB:AE000657 percent identity: 70.37; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.647 |
| TM_0374 | dnaK | TM_0374 | TM_0373 | Heat shock protein, class I; Similar to GB:AE000657 percent identity: 70.37; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.942 |
| TM_0374 | groS | TM_0374 | TM_0505 | Heat shock protein, class I; Similar to GB:AE000657 percent identity: 70.37; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | groES protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.472 |
| TM_0374 | grpE | TM_0374 | TM_0850 | Heat shock protein, class I; Similar to GB:AE000657 percent identity: 70.37; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | grpE protein, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | 0.695 |
| TM_0374 | hrcA | TM_0374 | TM_0851 | Heat shock protein, class I; Similar to GB:AE000657 percent identity: 70.37; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | Heat shock operon repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.420 |
| TM_0990 | dnaJ | TM_0990 | TM_0849 | Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 71.88; identified by sequence similarity; putative. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.911 |
| TM_0990 | dnaK | TM_0990 | TM_0373 | Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 71.88; identified by sequence similarity; putative. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.958 |
| TM_0990 | groL | TM_0990 | TM_0506 | Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 71.88; identified by sequence similarity; putative. | groEL protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.597 |
| TM_1391 | TM_0374 | TM_1391 | TM_0374 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 73.97; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Heat shock protein, class I; Similar to GB:AE000657 percent identity: 70.37; identified by sequence similarity; putative; Belongs to the small heat shock protein (HSP20) family. | 0.819 |
| TM_1391 | dnaJ | TM_1391 | TM_0849 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 73.97; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.783 |
| TM_1391 | dnaK | TM_1391 | TM_0373 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 73.97; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.960 |
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