STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iolGDehydrogenase; Catalyzes the NAD(+)-dependent oxidation of myo-inositol (MI) to 2-keto-myo-inositol (scyllo-inosose), and thus probably functions in a myo-inositol degradation pathway together with IolM, IolN and IolO. Has no activity with scyllo-inositol and much reduced activity (78-fold lower catalytic efficiency) with 1D-chiro-inositol. Belongs to the Gfo/Idh/MocA family. (334 aa)    
Predicted Functional Partners:
iolM
Alcohol dehydrogenase, zinc-containing; Catalyzes the NAD(+)-dependent oxidation of scyllo-inosose (2-keto-myo-inositol) to 3-dehydro-scyllo-inosose (diketo-inositol), and thus probably functions in a myo-inositol degradation pathway together with IolG, IolN and IolO. Has no activity on myo-inositol, D- chiro-inositol and 1-keto-D-chiro-inositol. Belongs to the zinc-containing alcohol dehydrogenase family.
 
 
 0.999
suhB
Inositol monophosphatase family protein, putative; Phosphatase with broad specificity; it can dephosphorylate fructose 1,6-bisphosphate, both D and L isomers of inositol-1-phosphate (I-1-P) but displaying a 20-fold higher rate of hydrolysis of D-I-1-P than of the L isomer, 2'-AMP, pNPP, inositol-2-phosphate, beta-glycerol phosphate, and alpha-D-glucose-1-phosphate. Cannot hydrolyze glucose-6- phosphate, fructose-6-phosphate, 5'-AMP and NAD(+). May be involved in the biosynthesis of a unique osmolyte, di-myo-inositol 1,1-phosphate.
    
 0.991
iolO
D-tagatose 3-epimerase-related protein; Catalyzes the reversible epimerization between 5-keto-L- gluconate (5-dehydro-L-gluconate) and D-tagaturonate, and thus probably functions in a myo-inositol degradation pathway together with IolG, IolM and IolN. Is not active on the enantiomer 5- keto-D-gluconate. Was also shown to be a nonphosphorylated sugar isomerase with broad substrate specificity in vitro. Is able to catalyze the reversible C3- epimerization of L-ribulose to L-xylulose, D-ribulose to D-xylulose, D- psicose to D-fructose, and D-tagatose to D-sorbose, with a substrate prefere [...]
 
 
 0.948
TM_0415
Hypothetical protein; Identified by sequence similarity; putative.
 
 
 0.879
iolN
Creatinine amidohydrolase, putative; Catalyzes the ring-opening hydrolysis of 3-dehydro-scyllo- inosose (diketo-inositol) to 5-dehydro-L-gluconate, and thus probably functions in a myo-inositol degradation pathway together with IolG, IolM and IolO; Belongs to the creatininase superfamily.
 
  
 0.874
TM_0422
Conserved hypothetical protein; Similar to GP:3172553 percent identity: 56.37; identified by sequence similarity; putative.
 
 
 0.730
TM_0411
Transcriptional regulator, XylR-related; Similar to PID:1924925 PID:2398723 percent identity: 54.17; identified by sequence similarity; putative.
       0.645
TM_0418
Sugar ABC transporter, periplasmic sugar-binding protein, putative; Similar to PID:1850900 GB:AE000512 percent identity: 47.11; identified by sequence similarity; putative.
 
  
 0.560
TM_0789
Hypothetical protein; Identified by sequence similarity; putative.
  
 
 0.545
lysS
lysyl-tRNA synthetase; Similar to PID:567884 SP:Q53638 percent identity: 72.67; identified by sequence similarity; putative; Belongs to the class-II aminoacyl-tRNA synthetase family.
  
    0.535
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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