STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
iolOD-tagatose 3-epimerase-related protein; Catalyzes the reversible epimerization between 5-keto-L- gluconate (5-dehydro-L-gluconate) and D-tagaturonate, and thus probably functions in a myo-inositol degradation pathway together with IolG, IolM and IolN. Is not active on the enantiomer 5- keto-D-gluconate. Was also shown to be a nonphosphorylated sugar isomerase with broad substrate specificity in vitro. Is able to catalyze the reversible C3- epimerization of L-ribulose to L-xylulose, D-ribulose to D-xylulose, D- psicose to D-fructose, and D-tagatose to D-sorbose, with a substrate prefere [...] (270 aa)    
Predicted Functional Partners:
iolN
Creatinine amidohydrolase, putative; Catalyzes the ring-opening hydrolysis of 3-dehydro-scyllo- inosose (diketo-inositol) to 5-dehydro-L-gluconate, and thus probably functions in a myo-inositol degradation pathway together with IolG, IolM and IolO; Belongs to the creatininase superfamily.
 
 
 0.999
iolG
Dehydrogenase; Catalyzes the NAD(+)-dependent oxidation of myo-inositol (MI) to 2-keto-myo-inositol (scyllo-inosose), and thus probably functions in a myo-inositol degradation pathway together with IolM, IolN and IolO. Has no activity with scyllo-inositol and much reduced activity (78-fold lower catalytic efficiency) with 1D-chiro-inositol. Belongs to the Gfo/Idh/MocA family.
 
 
 0.948
iolM
Alcohol dehydrogenase, zinc-containing; Catalyzes the NAD(+)-dependent oxidation of scyllo-inosose (2-keto-myo-inositol) to 3-dehydro-scyllo-inosose (diketo-inositol), and thus probably functions in a myo-inositol degradation pathway together with IolG, IolN and IolO. Has no activity on myo-inositol, D- chiro-inositol and 1-keto-D-chiro-inositol. Belongs to the zinc-containing alcohol dehydrogenase family.
 
  
 0.946
uxaC
Uronate isomerase, putative; Similar to SP:P42607 PID:606033 GB:U00096 PID:2367192 percent identity: 58.33; identified by sequence similarity; putative; Belongs to the metallo-dependent hydrolases superfamily. Uronate isomerase family.
    
  0.928
TM_1062
Beta-glucuronidase; Similar to PID:642973 PID:14446 PID:412358 percent identity: 57.73; identified by sequence similarity; putative; Belongs to the glycosyl hydrolase 2 family.
    
  0.926
TM_0415
Hypothetical protein; Identified by sequence similarity; putative.
 
 
 0.904
TM_0426
PHT4-related protein; Similar to GB:D13229 PID:295711 percent identity: 54.73; identified by sequence similarity; putative.
 
 
 0.684
TM_0411
Transcriptional regulator, XylR-related; Similar to PID:1924925 PID:2398723 percent identity: 54.17; identified by sequence similarity; putative.
    
  0.668
TM_0312
Conserved hypothetical protein; Similar to SP:Q04869 PID:984688 percent identity: 59.38; identified by sequence similarity; putative.
 
 
 0.633
TM_0425
Oxidoreductase, putative; Similar to GB:AL009126 percent identity: 48.08; identified by sequence similarity; putative.
 
 
 0.632
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.