| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TM_0268 | folA | TM_0268 | TM_1641 | 5-methyltetrahydrofolate S-homocysteine methyltransferase; Similar to GB:U00017 PID:466997 percent identity: 54.29; identified by sequence similarity; putative. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.970 |
| TM_0268 | folD | TM_0268 | TM_1767 | 5-methyltetrahydrofolate S-homocysteine methyltransferase; Similar to GB:U00017 PID:466997 percent identity: 54.29; identified by sequence similarity; putative. | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.730 |
| TM_0268 | gcvT | TM_0268 | TM_0211 | 5-methyltetrahydrofolate S-homocysteine methyltransferase; Similar to GB:U00017 PID:466997 percent identity: 54.29; identified by sequence similarity; putative. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.977 |
| TM_0268 | glyA | TM_0268 | TM_0720 | 5-methyltetrahydrofolate S-homocysteine methyltransferase; Similar to GB:U00017 PID:466997 percent identity: 54.29; identified by sequence similarity; putative. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.977 |
| TM_0268 | purH | TM_0268 | TM_1249 | 5-methyltetrahydrofolate S-homocysteine methyltransferase; Similar to GB:U00017 PID:466997 percent identity: 54.29; identified by sequence similarity; putative. | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Similar to GB:AE000657 percent identity: 61.39; identified by sequence similarity; putative. | 0.957 |
| TM_0268 | purN | TM_0268 | TM_1248 | 5-methyltetrahydrofolate S-homocysteine methyltransferase; Similar to GB:U00017 PID:466997 percent identity: 54.29; identified by sequence similarity; putative. | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.957 |
| TM_0268 | thyX | TM_0268 | TM_0449 | 5-methyltetrahydrofolate S-homocysteine methyltransferase; Similar to GB:U00017 PID:466997 percent identity: 54.29; identified by sequence similarity; putative. | Thy1 protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant. | 0.957 |
| folA | TM_0268 | TM_1641 | TM_0268 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 5-methyltetrahydrofolate S-homocysteine methyltransferase; Similar to GB:U00017 PID:466997 percent identity: 54.29; identified by sequence similarity; putative. | 0.970 |
| folA | folD | TM_1641 | TM_1767 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 0.509 |
| folA | gcvT | TM_1641 | TM_0211 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.978 |
| folA | glyA | TM_1641 | TM_0720 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.977 |
| folA | purH | TM_1641 | TM_1249 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Phosphoribosylaminoimidazolecarboxamide formyltransferase/IMP cyclohydrolase; Similar to GB:AE000657 percent identity: 61.39; identified by sequence similarity; putative. | 0.960 |
| folA | purN | TM_1641 | TM_1248 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Phosphoribosylglycinamide formyltransferase; Catalyzes the transfer of a formyl group from 10- formyltetrahydrofolate to 5-phospho-ribosyl-glycinamide (GAR), producing 5-phospho-ribosyl-N-formylglycinamide (FGAR) and tetrahydrofolate. | 0.958 |
| folA | tdk | TM_1641 | TM_0401 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Thymidine kinase; Similar to GB:U00089 SP:P75070 PID:1673767 percent identity: 57.80; identified by sequence similarity; putative. | 0.565 |
| folA | thyX | TM_1641 | TM_0449 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Thy1 protein; Catalyzes the reductive methylation of 2'-deoxyuridine-5'- monophosphate (dUMP) to 2'-deoxythymidine-5'-monophosphate (dTMP) while utilizing 5,10-methylenetetrahydrofolate (mTHF) as the methyl donor, and NAD(P)H and FADH(2) as the reductant. | 0.975 |
| folA | tmk | TM_1641 | TM_1099 | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | Thymidylate kinase; Phosphorylation of dTMP to form dTDP in both de novo and salvage pathways of dTTP synthesis; Belongs to the thymidylate kinase family. | 0.533 |
| folD | TM_0268 | TM_1767 | TM_0268 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | 5-methyltetrahydrofolate S-homocysteine methyltransferase; Similar to GB:U00017 PID:466997 percent identity: 54.29; identified by sequence similarity; putative. | 0.730 |
| folD | folA | TM_1767 | TM_1641 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Dihydrofolate reductase; Key enzyme in folate metabolism. Catalyzes an essential reaction for de novo glycine and purine synthesis, and for DNA precursor synthesis (By similarity). | 0.509 |
| folD | gcvT | TM_1767 | TM_0211 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Aminomethyltransferase; The glycine cleavage system catalyzes the degradation of glycine. | 0.990 |
| folD | glyA | TM_1767 | TM_0720 | Methylenetetrahydrofolate dehydrogenase/methenyltetrahydrofolate cyclohydrolase; Catalyzes the oxidation of 5,10-methylenetetrahydrofolate to 5,10-methenyltetrahydrofolate and then the hydrolysis of 5,10- methenyltetrahydrofolate to 10-formyltetrahydrofolate. | Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism. | 0.990 |
