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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
trpB2Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine. (422 aa)    
Predicted Functional Partners:
trpA
Tryptophan synthase, alpha subunit; The alpha subunit is responsible for the aldol cleavage of indoleglycerol phosphate to indole and glyceraldehyde 3-phosphate. Belongs to the TrpA family.
  
 0.999
trpC
Indole-3-glycerol phosphate synthase; Similar to SP:Q56319 PID:1333731 GB:AE000512 percent identity: 99.60; identified by sequence similarity; putative; Belongs to the TrpC family.
 
 
 0.997
trpB1
Tryptophan synthase, beta subunit; The beta subunit is responsible for the synthesis of L- tryptophan from indole and L-serine.
  
 
0.993
TM_0356
Threonine dehydratase catabolic; Similar to GB:M21312 SP:P05792 GB:X14430 PID:147923 PID:43043 percent identity: 74.37; identified by sequence similarity; putative.
     
 0.991
glyA
Serine hydroxymethyltransferase; Catalyzes the reversible interconversion of serine and glycine with tetrahydrofolate (THF) serving as the one-carbon carrier. This reaction serves as the major source of one-carbon groups required for the biosynthesis of purines, thymidylate, methionine, and other important biomolecules. Also exhibits THF-independent aldolase activity toward beta-hydroxyamino acids, producing glycine and aldehydes, via a retro-aldol mechanism.
    
  0.991
TM_0538
Cation efflux system protein; Similar to GB:Pyro_h percent identity: 81.18; identified by sequence similarity; putative; Belongs to the cation diffusion facilitator (CDF) transporter (TC 2.A.4) family.
       0.752
trpF
Phosphoribosylanthranilate isomerase; Similar to PID:1054860 SP:Q56320 GB:AE000512 percent identity: 100.00; identified by sequence similarity; putative.
   
 0.713
TM_0542
Malate oxidoreductase; Similar to GP:1006839 percent identity: 70.94; identified by sequence similarity; putative.
       0.577
TM_0540
Fumarate hydratase, N-terminal subunit; Similar to GB:AE000657 percent identity: 62.92; identified by sequence similarity; putative.
       0.574
TM_0541
Fumarate hydratase, C-terminal subunit; Similar to GB:AE000657 percent identity: 67.28; identified by sequence similarity; putative.
       0.562
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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