STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM_0543Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 59.61; identified by sequence similarity; putative. (412 aa)    
Predicted Functional Partners:
TM_0544
ABC transporter, ATP-binding protein; Similar to GB:Pyro_h percent identity: 64.44; identified by sequence similarity; putative.
 
 
 0.957
TM_0547
Aspartokinase II; Similar to PID:928811 SP:P53553 percent identity: 67.00; identified by sequence similarity; putative.
   
   0.776
thrB
Homoserine kinase, putative; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
       0.762
TM_0546
Threonine synthase; Catalyzes the gamma-elimination of phosphate from L- phosphohomoserine and the beta-addition of water to produce L- threonine.
       0.762
cimA
2-isopropylmalate synthase, putative; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
 
     0.590
TM_1327
ABC transporter, ATP-binding protein; Similar to SP:P46903 PID:973330 PID:2415726 GB:AL009126 percent identity: 64.22; identified by sequence similarity; putative.
 
 
 0.553
TM_0071
Oligopeptide ABC transporter, periplasmic oligopeptide-binding protein; Similar to PID:1143602 percent identity: 84.56; identified by sequence similarity; putative.
  
  
  0.525
TM_0548
Acetolactate synthase, large subunit; Similar to GB:AE000782 percent identity: 71.85; identified by sequence similarity; putative.
       0.510
TM_0549
Acetolactate synthase, small subunit; Similar to GB:AE000782 percent identity: 72.96; identified by sequence similarity; putative.
       0.510
ilvC
Ketol-acid reductoisomerase; Involved in the biosynthesis of branched-chain amino acids (BCAA). Catalyzes an alkyl-migration followed by a ketol-acid reduction of (S)-2-acetolactate (S2AL) to yield (R)-2,3-dihydroxy-isovalerate. In the isomerase reaction, S2AL is rearranged via a Mg-dependent methyl migration to produce 3-hydroxy-3-methyl-2-ketobutyrate (HMKB). In the reductase reaction, this 2-ketoacid undergoes a metal-dependent reduction by NADPH to yield (R)-2,3-dihydroxy-isovalerate.
       0.510
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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