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STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM_0594Conserved hypothetical protein; Similar to GB:L77117 SP:Q57772 PID:1591045 percent identity: 76.92; identified by sequence similarity; putative. (461 aa)    
Predicted Functional Partners:
TM_0593
Amino acid ABC transporter, periplasmic amino acid-binding protein; Similar to GB:AE000782 percent identity: 64.68; identified by sequence similarity; putative.
       0.651
TM_0591
Amino acid ABC transporter, ATP-binding protein; Similar to GB:AE000782 percent identity: 80.08; identified by sequence similarity; putative.
       0.630
TM_0592
Amino acid ABC transporter, permease protein; Similar to GB:AE000782 percent identity: 72.86; identified by sequence similarity; putative.
       0.630
TM_0595
Sugar ABC transporter, periplasmic sugar-binding protein, putative; Similar to SP:P10904 GB:U00039 GB:M33735 PID:43244 PID:466589 percent identity: 48.57; identified by sequence similarity; putative.
       0.608
purE
Phosphoribosylaminoimidazole carboxylase, catalytic subunit; Catalyzes the conversion of N5-carboxyaminoimidazole ribonucleotide (N5-CAIR) to 4-carboxy-5-aminoimidazole ribonucleotide (CAIR).
  
    0.529
purK
Phosphoribosylaminoimidazole carboxylase, ATPase subunit; Catalyzes the ATP-dependent conversion of 5-aminoimidazole ribonucleotide (AIR) and HCO(3)(-) to N5-carboxyaminoimidazole ribonucleotide (N5-CAIR).
  
    0.521
guaA
GMP synthase; Catalyzes the synthesis of GMP from XMP.
     
 0.511
purL
Phosphoribosylformylglycinamidine synthase II; Part of the phosphoribosylformylglycinamidine synthase complex involved in the purines biosynthetic pathway. Catalyzes the ATP-dependent conversion of formylglycinamide ribonucleotide (FGAR) and glutamine to yield formylglycinamidine ribonucleotide (FGAM) and glutamate. The FGAM synthase complex is composed of three subunits. PurQ produces an ammonia molecule by converting glutamine to glutamate. PurL transfers the ammonia molecule to FGAR to form FGAM in an ATP- dependent manner. PurS interacts with PurQ and PurL and is thought to assist [...]
  
  
 0.498
purD
Phosphoribosylamine--glycine ligase; Similar to GB:AE000657 percent identity: 62.47; identified by sequence similarity; putative.
  
  
 0.485
purC
Phosphoribosylaminoimidazole-succinocarboxamide synthase; Similar to GB:L77117 PID:1592203 percent identity: 68.02; identified by sequence similarity; putative; Belongs to the SAICAR synthetase family.
  
  
 0.480
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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