Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene fusion
Co-occurrence
Co-expression
Experiments
Databases
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[Homology]
Score
TM_0716propionyl-CoA carboxylase, beta subunit; Similar to PID:1177652 SP:P53003 percent identity: 76.31; identified by sequence similarity; putative. (515 aa)    
Predicted Functional Partners:
TM_0717
propionyl-CoA carboxylase, gamma subunit; Similar to GP:2706400 percent identity: 51.91; identified by sequence similarity; putative.
 
 0.915
TM_0224
biotin--(acetyl-CoA carboxylase) synthetase; Similar to GB:AE000666 percent identity: 57.33; identified by sequence similarity; putative.
 
 
 0.834
TM_0715
tRNA nucleotidyl transferase-related protein; Similar to GB:AE000657 percent identity: 56.71; identified by sequence similarity; putative; Belongs to the tRNA nucleotidyltransferase/poly(A) polymerase family.
       0.827
TM_0713
Hypothetical protein; Identified by sequence similarity; putative.
  
    0.821
TM_0714
Hypothetical protein; Identified by sequence similarity; putative.
       0.813
TM_0712
Conserved hypothetical protein; Similar to GB:AL009126 percent identity: 55.24; identified by sequence similarity; putative.
  
  
 0.671
TM_0711
Hypothetical protein; Identified by sequence similarity; putative.
   
   0.658
cimA
2-isopropylmalate synthase, putative; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
  
 0.600
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
  
 0.600
TM_0290
Citrate synthase; Similar to GB:AE000782 percent identity: 66.39; identified by sequence similarity; putative; Belongs to the citrate synthase family.
  
 
 0.590
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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