STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM_0748Conserved hypothetical protein; Catalyzes the S-adenosyl-L-methionine-dependent formation of N(1)-methyladenine at position 58 (m1A58) in tRNA. (265 aa)    
Predicted Functional Partners:
ttuA
Conserved hypothetical protein; Catalyzes the ATP-dependent 2-thiolation of 5-methyluridine residue at position 54 in the T loop of tRNAs, leading to 5-methyl-2- thiouridine (m(5)s(2)U or s(2)T). This modification allows thermal stabilization of tRNAs in thermophilic microorganisms, and is required for cell growth at high temperatures (By similarity). Can use free sulfide as sulfur source in vitro. Belongs to the TtcA family. TtuA subfamily.
 
  
 0.846
TM_0751
Uridine kinase-related protein; Similar to GB:U00089 SP:P75217 PID:1673952 percent identity: 52.11; identified by sequence similarity; putative.
  
    0.832
TM_0743
Hypothetical protein; Identified by sequence similarity; putative.
       0.826
TM_0747
Carboxyl-terminal protease; Similar to GB:AE000657 percent identity: 62.56; identified by sequence similarity; putative; Belongs to the peptidase S41A family.
       0.826
trmB
Conserved hypothetical protein; Catalyzes the formation of N(7)-methylguanine at position 46 (m7G46) in tRNA.
  
 0.814
TM_0739
Hypothetical protein; Identified by sequence similarity; putative.
       0.810
thrS
threonyl-tRNA synthetase; Catalyzes the attachment of threonine to tRNA(Thr) in a two- step reaction: L-threonine is first activated by ATP to form Thr-AMP and then transferred to the acceptor end of tRNA(Thr). Also edits incorrectly charged L-seryl-tRNA(Thr).
       0.810
coaD
Lipopolysaccharide core biosynthesis protein KdtB; Reversibly transfers an adenylyl group from ATP to 4'- phosphopantetheine, yielding dephospho-CoA (dPCoA) and pyrophosphate. Belongs to the bacterial CoaD family.
       0.810
TM_0742
Serine/threonine protein phosphatase; Similar to GP:2760343 percent identity: 57.14; identified by sequence similarity; putative.
       0.810
TM_0744
Conserved hypothetical protein; Similar to GB:Pyro_h percent identity: 56.78; identified by sequence similarity; putative.
       0.810
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
Server load: low (38%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.