STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Knowledge-based Evidence
from curated databases
textmining
Assay-based Predictions
experimentally determined
co-expression
Genomic Predictions
gene neighborhood
gene co-occurrence
gene fusions
Your Input:
Neighborhood
Gene Fusion
Co-occurrence
Co-expression
Experiments
Databases
Textmining
[Homology]
Score
ilvEBranched-chain amino acid aminotransferase, putative; Acts on leucine, isoleucine and valine; Belongs to the class-IV pyridoxal-phosphate-dependent aminotransferase family. (273 aa)    
Predicted Functional Partners:
ilvD
Dihydroxy-acid dehydratase; Similar to GB:AE000657 percent identity: 73.96; identified by sequence similarity; putative; Belongs to the IlvD/Edd family.
  
 0.997
leuA
2-isopropylmalate synthase; Catalyzes the condensation of the acetyl group of acetyl-CoA with 3-methyl-2-oxobutanoate (2-oxoisovalerate) to form 3-carboxy-3- hydroxy-4-methylpentanoate (2-isopropylmalate); Belongs to the alpha-IPM synthase/homocitrate synthase family. LeuA type 1 subfamily.
 
 0.990
cimA
2-isopropylmalate synthase, putative; Catalyzes the condensation of pyruvate and acetyl-coenzyme A to form (R)-citramalate.
  
 0.986
TM_0547
Aspartokinase II; Similar to PID:928811 SP:P53553 percent identity: 67.00; identified by sequence similarity; putative.
  
 
 0.973
trpGD
Anthranilate synthase component II; Part of a heterotetrameric complex that catalyzes the two- step biosynthesis of anthranilate, an intermediate in the biosynthesis of L-tryptophan. In the first step, the glutamine-binding beta subunit (TrpG) of anthranilate synthase (AS) provides the glutamine amidotransferase activity which generates ammonia as a substrate that, along with chorismate, is used in the second step, catalyzed by the large alpha subunit of AS (TrpE) to produce anthranilate. In the absence of TrpG, TrpE can synthesize anthranilate directly from chorismate and high concent [...]
 
 
 0.970
panB
3-methyl-2-oxobutanoate hydroxymethyltransferase; Catalyzes the reversible reaction in which hydroxymethyl group from 5,10-methylenetetrahydrofolate is transferred onto alpha- ketoisovalerate to form ketopantoate; Belongs to the PanB family.
    
 0.969
TM_0356
Threonine dehydratase catabolic; Similar to GB:M21312 SP:P05792 GB:X14430 PID:147923 PID:43043 percent identity: 74.37; identified by sequence similarity; putative.
  
 0.953
TM_0155
Chorismate mutase/prephenate dehydratase; Similar to GB:AE000782 percent identity: 80.45; identified by sequence similarity; putative.
    
 0.951
thrB
Homoserine kinase, putative; Catalyzes the ATP-dependent phosphorylation of L-homoserine to L-homoserine phosphate; Belongs to the GHMP kinase family. Homoserine kinase subfamily.
 
 
 0.914
ldh
L-lactate dehydrogenase; Catalyzes the conversion of lactate to pyruvate. It is stereospecific for L(+)-lactate.
  
 0.912
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
Server load: low (26%) [HD]
STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.