| node1 | node2 | node1 accession | node2 accession | node1 annotation | node2 annotation | score |
| TM_0198 | clpP | TM_0198 | TM_0695 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.927 |
| TM_0198 | dnaJ | TM_0198 | TM_0849 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.783 |
| TM_0198 | dnaK | TM_0198 | TM_0373 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.960 |
| TM_0198 | groL | TM_0198 | TM_0506 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | groEL protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.633 |
| TM_0198 | groS | TM_0198 | TM_0505 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | groES protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.645 |
| TM_0198 | grpE | TM_0198 | TM_0850 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | grpE protein, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | 0.798 |
| TM_0198 | hrcA | TM_0198 | TM_0851 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Heat shock operon repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.539 |
| TM_0852 | dnaJ | TM_0852 | TM_0849 | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.449 |
| TM_0852 | grpE | TM_0852 | TM_0850 | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | grpE protein, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | 0.477 |
| TM_0852 | hrcA | TM_0852 | TM_0851 | Conserved hypothetical protein; Required for the formation of a threonylcarbamoyl group on adenosine at position 37 (t(6)A37) in tRNAs that read codons beginning with adenine. | Heat shock operon repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.518 |
| TM_1391 | clpP | TM_1391 | TM_0695 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 73.97; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | 0.927 |
| TM_1391 | dnaJ | TM_1391 | TM_0849 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 73.97; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.783 |
| TM_1391 | dnaK | TM_1391 | TM_0373 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 73.97; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | dnaK protein; Acts as a chaperone; Belongs to the heat shock protein 70 family. | 0.960 |
| TM_1391 | groL | TM_1391 | TM_0506 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 73.97; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | groEL protein; Prevents misfolding and promotes the refolding and proper assembly of unfolded polypeptides generated under stress conditions. | 0.633 |
| TM_1391 | groS | TM_1391 | TM_0505 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 73.97; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | groES protein; Binds to Cpn60 in the presence of Mg-ATP and suppresses the ATPase activity of the latter. | 0.645 |
| TM_1391 | grpE | TM_1391 | TM_0850 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 73.97; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | grpE protein, putative; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins, in association with DnaK and GrpE. It is the nucleotide exchange factor for DnaK and may function as a thermosensor. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-d [...] | 0.798 |
| TM_1391 | hrcA | TM_1391 | TM_0851 | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 73.97; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | Heat shock operon repressor HrcA; Negative regulator of class I heat shock genes (grpE-dnaK- dnaJ and groELS operons). Prevents heat-shock induction of these operons. | 0.539 |
| clpP | TM_0198 | TM_0695 | TM_0198 | ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 74.36; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | 0.927 |
| clpP | TM_1391 | TM_0695 | TM_1391 | ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | ATP-dependent Clp protease, ATPase subunit; Similar to PID:1001492 percent identity: 73.97; identified by sequence similarity; putative; Belongs to the ClpA/ClpB family. | 0.927 |
| clpP | dnaJ | TM_0695 | TM_0849 | ATP-dependent Clp protease, proteolytic subunit; Cleaves peptides in various proteins in a process that requires ATP hydrolysis. Has a chymotrypsin-like activity. Plays a major role in the degradation of misfolded proteins. Belongs to the peptidase S14 family. | dnaJ protein; Participates actively in the response to hyperosmotic and heat shock by preventing the aggregation of stress-denatured proteins and by disaggregating proteins, also in an autonomous, DnaK-independent fashion. Unfolded proteins bind initially to DnaJ; upon interaction with the DnaJ-bound protein, DnaK hydrolyzes its bound ATP, resulting in the formation of a stable complex. GrpE releases ADP from DnaK; ATP binding to DnaK triggers the release of the substrate protein, thus completing the reaction cycle. Several rounds of ATP-dependent interactions between DnaJ, DnaK and Gr [...] | 0.638 |
STRING v12.5 is now available!
