STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
larCConserved hypothetical protein; Involved in the biosynthesis of a nickel-pincer cofactor ((SCS)Ni(II) pincer complex). Binds Ni(2+), and functions in nickel delivery to pyridinium-3,5-bisthiocarboxylic acid mononucleotide (P2TMN), to form the mature cofactor. Is thus probably required for the activation of nickel-pincer cofactor-dependent enzymes. Belongs to the LarC family. (402 aa)    
Predicted Functional Partners:
TM_0966
Conserved hypothetical protein; Similar to PID:1652988 percent identity: 67.30; identified by sequence similarity; putative.
 
 0.997
TM_0965
Phosphoribosylaminoimidazole carboxylase-related protein; Similar to GB:L77117 SP:Q57629 PID:1498937 percent identity: 63.45; identified by sequence similarity; putative.
  
 0.993
TM_0442
Conserved hypothetical protein; Similar to PID:609549 percent identity: 54.77; identified by sequence similarity; putative.
 
  
 0.785
pyrG
CTP synthetase; Catalyzes the ATP-dependent amination of UTP to CTP with either L-glutamine or ammonia as the source of nitrogen. Regulates intracellular CTP levels through interactions with the four ribonucleotide triphosphates.
 
      0.717
TM_0963
Oligoendopeptidase, putative; Similar to GB:AE000783 percent identity: 49.88; identified by sequence similarity; putative.
       0.529
TM_1075
Hypothetical protein; Identified by sequence similarity; putative.
  
  
 0.455
TM_0049
Iron-sulfur cluster-binding protein; Similar to GB:AE000666 percent identity: 56.54; identified by sequence similarity; putative.
 
     0.423
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.