STRINGSTRING
STRING protein interaction network
Nodes:
Network nodes represent proteins
splice isoforms or post-translational modifications are collapsed, i.e. each node represents all the proteins produced by a single, protein-coding gene locus.
Node Color
colored nodes:
query proteins and first shell of interactors
white nodes:
second shell of interactors
Node Content
empty nodes:
proteins of unknown 3D structure
filled nodes:
a 3D structure is known or predicted
Edges:
Edges represent protein-protein associations
associations are meant to be specific and meaningful, i.e. proteins jointly contribute to a shared function; this does not necessarily mean they are physically binding to each other.
Known Interactions
from curated databases
experimentally determined
Predicted Interactions
gene neighborhood
gene fusions
gene co-occurrence
Others
textmining
co-expression
protein homology
Your Input:
Neighborhood
Gene Fusion
Cooccurrence
Coexpression
Experiments
Databases
Textmining
[Homology]
Score
TM_0967Integrase-recombinase protein; Similar to GB:AE000666 percent identity: 63.05; identified by sequence similarity; putative; Belongs to the 'phage' integrase family. (253 aa)    
Predicted Functional Partners:
TM_1584
comFC protein, putative; Similar to GB:L14437 SP:P39147 PID:451867 PID:580842 PID:1762334 percent identity: 49.74; identified by sequence similarity; putative.
   
    0.707
apt
Adenine phosphoribosyltransferase; Catalyzes a salvage reaction resulting in the formation of AMP, that is energically less costly than de novo synthesis.
   
    0.700
mfd
Transcription-repair coupling factor, putative; Couples transcription and DNA repair by recognizing RNA polymerase (RNAP) stalled at DNA lesions. Mediates ATP-dependent release of RNAP and its truncated transcript from the DNA, and recruitment of nucleotide excision repair machinery to the damaged site; In the C-terminal section; belongs to the helicase family. RecG subfamily.
  
   
 0.629
TM_0344
Prephenate dehydrogenase; Similar to PID:1653053 percent identity: 49.42; identified by sequence similarity; putative.
  
    0.603
TM_0968
Conserved hypothetical protein; Similar to SP:P05332 GB:X07542 PID:39573 percent identity: 51.81; identified by sequence similarity; putative.
     
 0.578
whiA
Conserved hypothetical protein; Involved in cell division and chromosome segregation. Belongs to the WhiA family.
   
    0.562
pgk/tpi
Phosphoglycerate kinase/triose-phosphate isomerase; Similar to PIR:S54289 percent identity: 99.69; identified by sequence similarity; putative; In the N-terminal section; belongs to the phosphoglycerate kinase family.
   
 
 0.543
topA
DNA topoisomerase; Releases the supercoiling and torsional tension of DNA, which is introduced during the DNA replication and transcription, by transiently cleaving and rejoining one strand of the DNA duplex. Introduces a single-strand break via transesterification at a target site in duplex DNA. The scissile phosphodiester is attacked by the catalytic tyrosine of the enzyme, resulting in the formation of a DNA- (5'-phosphotyrosyl)-enzyme intermediate and the expulsion of a 3'-OH DNA strand. The free DNA strand then undergoes passage around the unbroken strand, thus removing DNA superc [...]
 
  
 0.542
TM_0250
DNA processing chain A; Similar to GB:L42023 SP:P43862 PID:1006171 PID:1221098 PID:609332 percent identity: 61.21; identified by sequence similarity; putative.
 
   
 0.521
polA
DNA-directed DNA polymerase I; In addition to polymerase activity, this DNA polymerase exhibits 5'-3' exonuclease activity; Belongs to the DNA polymerase type-A family.
  
  
 0.493
Your Current Organism:
Thermotoga maritima
NCBI taxonomy Id: 243274
Other names: T. maritima MSB8, Thermotoga maritima DSM 3109, Thermotoga maritima MSB8, Thermotoga maritima str. MSB8, Thermotoga maritima strain MSB8
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STRING is a Core Data Resource as designated by Global Biodata Coalition and ELIXIR.